Parkinson Disease
Conditions
Brief summary
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
Detailed description
The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.
Interventions
DEVICEaDBS
adaptive deep brain stimulation
Sponsors
University of Colorado, Denver
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG. \-
Exclusion criteria
Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| identification of L-beta frequency peak power | 4 weeks |
Countries
United States
Contacts
Primary ContactPamela David Gerecht, PhD
Outcome results
None listed