Cigarette Smoking, Nicotine Dependence, Tobacco Use
Conditions
Brief summary
Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.
Interventions
OTHERCigarettes
Participants will smoke their own usual brand cigarettes. Cigarette butts will be collected.
Sponsors
Masonic Cancer Center, University of Minnesota
National Cancer Institute (NCI)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Smoking at least 10 cigarettes/day for at least 1 year (confirmed by CO \> 8 ppm or NicAlert test of 6) * Engaging in relighting for at least half of their CPD * No smoking quit attempts in the past month nor intentions to quit in the next month * Stable medical or psychiatric conditions with systolic blood pressure \< 160, diastolic blood pressure \< 100 and heart rate \< 105 bpm
Exclusion criteria
* Participant with current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month * Currently trying or planning to quit smoking in the next month * Planning to become pregnant, pregnant or breastfeeding. Pregnancy exclusion will be confirmed through a urine test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Average Nicotine Level | 1 month | Level of nicotine in cigarette butts collected during study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Average Puff Volume | 1 month | In-clinic measurement of puff volume using topography device. |
Countries
United States
Outcome results
None listed