Anesthesia
Conditions
Keywords
esketamine, children, half effective dose, laser treatment
Brief summary
There is limited research on the combined use of esketamine and alfentanil for anesthesia during facial laser treatment in pediatric patients, and the effective dosage of esketamine for inhibiting body movement remains unclear. We explore the effective dose of esketamine combined with alfentanil for the inhibition of body movement during facial laser treatment in pediatric patients.
Interventions
DRUGEsketamine
esketamine will be given intravenously
Sponsors
Air Force Military Medical University, China
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
NONE
Masking description
Esketamine will be prepared by an investigator who is not involved in anesthesia and outcome assessment. For all participants, esketamine will be diluted to the same volume.
Intervention model description
The Biased coin method is used
Eligibility
Sex/Gender
ALL
Age
3 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* age between 3 years and 12 years old * patients scheduled for laser treatment of facial lesion
Exclusion criteria
* patients with airway infection during the last 1 month * patients with cardiac or pulmonary disorder * patients with hepatic or renal disfunction * patients with neurologic or psychiatric disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| half effective dose of inhibition of body movement | from injection of esketamine to start of laser treatment, in an average of 5 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| number of patients with agitation during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes | — |
| number of patients with dizzy during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes | — |
| number of patients with nausea and vomiting during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes | — |
| number of patients with apnea during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes | — |
| satisfaction score of the parents to the anesthesia | from end of laser treatment to discharge from the outpatient unit, in an average of 60 minutes | The satisfaction of the parents to the anesthesia will be assessed by visual analogue scale, of which 0 is for extremely not satisfied, 10 is for extremely satisfied |
Contacts
Primary ContactZhi-Hong Lu
Outcome results
None listed