Skip to content

Pleurodesis Using Hypertonic Glucose

PLeurodesis Using Hypertonic Glucose Administration to Treat Post-operative Air Leaks Following Lung Resection Surgery (PLUG): Phase II Randomized Feasibility Trial

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06293885
Acronym
PLUG-II
Enrollment
40
Registered
2024-03-05
Start date
2024-03-30
Completion date
2025-04-30
Last updated
2024-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Air Leak From Lung

Keywords

air leak

Brief summary

Air leaks from unhealed lung tissue following lung resection for benign or malignant lesions are one of the most common complications following thoracic surgery, occurring after 10% of major lung resections. The purpose of this study is to investigate the efficacy of intrapleural administration of Dextrose 50% to resolve air leaks after pulmonary resection.

Interventions

a solution of 50% glucose (D50) will be injected into your pleural space

OTHERStandard of Care - No Dextrose 50

Standard of Care

Sponsors

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patients undergoing scheduled pulmonary lobar or sublobar resection for cancer * Presence of air leak on postoperative day 1 of at least 100 mL/min, as documented on the digital drainage system

Exclusion criteria

\- None

Design outcomes

Primary

MeasureTime frameDescription
Prolonged Air Leak5 days postoperativelyProlonged Air Leak

Secondary

MeasureTime frameDescription
Duration of Chest Tubesimmediately after the surgeryDuration of Chest Tubes
Home with Chest Tubeimmediately after the surgeryHome with Chest Tube (y/n)

Countries

Canada

Contacts

Primary ContactDeb Lewis
deb.lewis@lhsc.on.ca519-685-8500

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026