Application of the Web-based Acceptance and Commitment Therapy for Depression

The Efficacy and Treatment Mechanisms of the Web-based Acceptance and Commitment Therapy for Patients with Major Depressive Disorder

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06293781

Acronym

ACTION

Enrollment

Registered

2024-03-05

Start date

2022-12-19

Completion date

2025-02-28

Last updated

2024-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Brief summary

PROSPECTIVE INTERVENTION STUDY; EFFICACY OF WEB-BASED ACCEPTANCE AND COMMITMENT THERAPY

Detailed description

Acceptance Commitment Therapy (ACT) is known to help people recover from depression by improving psychological flexibility through acceptance, defusion, self-as-context, present moment, committed action, and helping them live a values-based life. This study is a randomized controlled trial to determine if web-based ACT leads to changes in the psychological flexibility and cognitive fusion. Also, through the functional MRI study, possible treatment mechanisms by which the web-based ACT exerts will be identified.

Interventions

DEVICEWeb-based ACT

ACT program delivered online

BEHAVIORALTreatment as usual

Treatment as usual for major depressive disorder

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients who diagnosed major depressive disorder

Exclusion criteria

* Patients who have serious medical problems, metal implants in their bodies, severe brain injury or brain disease * Women who were pregnant or nursing * Patients at high risk for suicide

Design outcomes

Primary

Measure	Time frame	Description
Acceptance and Action Questionnaire-II	6 weeks	Psychological flexibility
Hamilton Rating Scale for Depression	6 weeks	Interviewer-rated depression scale

Secondary

Measure	Time frame	Description
Valuing	6 weeks	Measuring one's valuing
Beck Depression Inventory	6 weeks	Measuring subjective depression
Cognitive Fusion Questionnaire	6 weeks	Cognitive fusion
Beck Hopelessness Scale	6 weeks	Measuring hopelessness by the Beck Hopelessness Scale
Beck Scale for Suicide Ideation	6 weeks	Measuring suicidality
Beck Anxiety Inventory	6 weeks	Measuring subjective anxiety
Functional Connectivity	6 weeks	functional connectivity of the brain during resting state

Countries

South Korea

Contacts

Primary ContactKyoung-Sae Na, MD, PhD

ksna13@gmail.com82324689932

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026