Chronic Kidney Disease stage3
Conditions
Keywords
Exercise, Dialysis, Kidney Failure, Chronic
Brief summary
the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease.
Detailed description
The patients of this study will randomly assigned into three equal groups (n=20) 1. Study Group A (20 patients) will receive intradialytic aerobic exercise and medical treatment. 2. Study Group B (20 patients) will receive intradialytic resistive exercise and medical treatment. 3. Control Group C (20 patients) will receive medical treatment only (HD session and drugs) Each patient will receive the treatment program three times per week for three months.
Interventions
DEVICEleg pedaling cycling device
Intradialytic aerobic cycling exercise program ,each patient will receive the treatment program three times per week for three months.
DEVICEsand bags
Intradialytic resistive exercise program , each patient will receive the treatment program three times per week for three months.
DEVICEhemodialysis sessions
hemodialysis sessions ,each patient will receive the treatment program three times per week for three months.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
control group receive medical treatment only ,first study group receive medical treatment and intradialytic aerobic exercise , second study group receive medical treatment and intradialytic resistive exercise
Eligibility
Sex/Gender
MALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Sixty men chronic kidney disease (grade III RF). They received regular hemodialysis sessions at least one year ago, each one for four hours, three times per week. * They had a history of type II Diabetes more than five years. * Their age will be ranged from 50-60 years old. * They are Fit for exercise by functional assessment using six minute walk test. * Their Hemoglobin level more than 10 g\\dl. * Their Body Mass Index (BMI) will be ranged from 18.5 to 24.9.
Exclusion criteria
* Severe cardiac disorders. * Severe orthopedic problems (for example fractures). * Hepatic encephalopathy. * Preexisting neuromuscular diseases (e.g. myasthenia gravis). •Severe chest diseases. * Spinal cord injuries involved the phrenic nerve. * Uncontrolled diabetes or hypertension * Patients receiving inefficient hemodialysis session. * Patients with other cause for inflammation e.g. malignancy and autoimmune disease. * Active bleeding as alveolar hemorrhage, hemoptysis. * Physical limitation that would limit cycling.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of immunoglobulin g | baseline , 12 weeks for each patient | measured by mg/dl |
| Total leukocyte count | baseline , 12 weeks for each patient | measured by (cell/mcl)\*\*\*\*1000 |
| lymphocyte count | baseline , 12 weeks for each patient | measured by (cell/mcl)\*\*\*\*1000 |
| neutrophil count | baseline , 12 weeks for each patient | measured by (cell/mcl)\*\*\*\*1000 |
| Concentration of HbA1c | baseline , 12 weeks for each patient | measured by percentage of blood sugar last 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hemoglobin concentration | baseline , 12 weeks for each patient | measured by (g/dl) |
| thrombocytes count | baseline , 12 weeks for each patient | measured by (cell/mcl)\*\*\*\*1000 |
| diastolic blood pressure | baseline , 12 weeks for each patient | measured by mmHg |
| Systolic blood pressure | baseline , 12 weeks for each patient | measured by mmHg |
| six minute walk test | baseline , 12 weeks for each patient | measured by meter |
| (KDQOL-SFTM) questionnaire | baseline , 12 weeks for each patient | measured by scoring a score-value from 0 (worst health status) to 100 (best health status) was obtained |
Countries
Egypt
Outcome results
None listed