Medullary Thyroid Cancer
Conditions
Brief summary
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.
Detailed description
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients \>18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.
Interventions
PROCEDURETotal Thyroidectomy
Total thyroidectomy
Sponsors
Aristotle University Of Thessaloniki
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection
Exclusion criteria
* Age \< 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Central lymph node metastasis | Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively | Central neck compartment lymph node metastasis |
| Lateral lymph node metastasis | Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively | Lateral neck compartment lymph node metastasis |
| Distant metastasis | Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively | Liver and lung metastasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Desmoplasia as histological predictor of aggressiveness | The pathology report is held immediately after surgery | desmoplasia |
| CEA as Biochemical predictor of aggressiveness | pre and postoperative laboratory exams up to 1 year postoperatively | Carcinoembryonic antigen (CEA) preoperatively and up to 1 year postoperatively |
| Calcitonin as Biochemical predictor of aggressiveness | pre and postoperative laboratory exams up to 1 year postoperatively | calcitonin levels preoperatively and up to 1 year postoperatively |
| Nuclear atypia as histological predictor of aggressiveness | The pathology report is held immediately after surgery | nuclear atypia |
| Platelet count as Biochemical predictor of aggressiveness | pre and postoperative laboratory exams up to 1 year postoperatively | platelet count |
| CEA drop as Biochemical cure marker | up to 1 year postoperatively | CEA drop levels |
| Calcitonin drop as Biochemical cure marker | up to 1 year postoperatively | calcitonin drop levels |
| White blood cell as Biochemical predictor of aggressiveness | pre and postoperative laboratory exams up to 1 year postoperatively | white blood cell count |
| Amyloid as histological predictor of aggressiveness | The pathology report is held immediately after surgery | amyloid |
| Immunohistochemistry as histological predictor of aggressiveness | The pathology report is held immediately after surgery | immunohistochemistry |
Countries
Austria, Belgium, Brazil, Bulgaria, China, Colombia, Croatia, France, Greece, India, Iraq, Italy, Jordan, Morocco, Poland, Serbia, Slovakia, Spain, Switzerland, Thailand, Turkey (Türkiye), Ukraine, United States, Vietnam
Outcome results
None listed