Ards, Pneumonia, Pneumothorax, Postoperative Pulmonary Atelectasis, Respiratory Failure
Conditions
Brief summary
During cardiopulmonary bypass (CPB), oxygenation of the patient on the pump can be left completely under pump control, or the lungs can be ventilated with low tidal volume to reduce atelectasis. In recent years, the concept of mechanical power has been used to determine the extent of ventilator-related lung damage. This concept of mechanical power, by which the energy transferred by the ventilator to the lungs can be calculated, will be measured at certain intervals in CPB surgery patients on the pump and compared between the two groups. The investigators aimed to investigate the effect of two different ventilation methods on mechanical power and its relationship with postoperative pulmonary complications.
Detailed description
Patients will be taken to the operating table after preoperative evaluation. Routine monitoring and routine anesthesia method will be applied to the patient. Access will be made through the radial artery for arterial catheterization. Patients will be ventilated with 6-8 ml/kg tidal volume, 12-14 frequency/min, 5 Positive end expiratory pressure(PEEP), 60% Fraction of inspired oxygen(FiO2) and oxygen saturation over 94. End tidal Carbon dixide(CO2) will be kept in the range of 32-37. After cardiac catheterizations are performed, the pump will be entered, and after all preparations are completed, an aortic cross-clamp will be placed and cardioplegic solution will be sent. After the patient enters the pump at full flow; Group 1: Non-ventilated patient group. Here, patients will be placed in the cardiac bypass mode of the anesthesia machine. Only 150 ml of free air flow will be provided and mechanical ventilation will be turned off. Group 2: Patients will continue to be ventilated at FiO2: 40%, TV: 3 ml/kg, frequency 12 breaths/min, peep: 5 cm/H2O.
Interventions
Mechanical Power= 0.098×Minute ventilation× (peak pressure - 0.5 (plato pressure-PEEP)). These parameters are monitored on the monitor while the patient is mechanically ventilated and placed into the equation
Sponsors
TC Erciyes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who will undergo elective cardiopulmonary bypass surgery and agree to participate in the study * Patients who will undergo coronary or valve surgery * Surgeries performed on a stopped heart * Patients over 18 years
Exclusion criteria
* Patients undergoing emergency cardiac surgery * Patients who will undergo redo surgery * Patients who will undergo total circulatory arrest surgery * Patients in a state of preoperative shock * Patients with acute and chronic hypoxemia (PaO2 \<65mmHg, SpO2 \<95 in room air) * Patients followed with mechanical ventilation for 7 days before surgery * Patients with BMI\>35 * Patients with obstructive sleep apnea syndrome * Patients with pulmonary artery pressure \>50 mmHg * Patients with glomerular filtration rate \<30 ml/min
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mechanical power | intraoperative | mechanical power=0.098\*minute ventilation \*(Ppeak-0.5\*(Pplato-PEEP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mechanical power | postoperative in intensive care unit | mechanical power=0.098\*minute ventilation \*(Ppeak-0.5\*(Pplato-PEEP) |
Countries
Turkey (Türkiye)
Outcome results
None listed