Mitochondrial Diseases, Blepharoptosis
Conditions
Brief summary
This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light. We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months. We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint.
Interventions
DEVICENear-infrared light
daily application of near-infrared light
Sponsors
Moorfields Eye Hospital NHS Foundation Trust
University College, London
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
Inclusion: Age 3 to less than 18 years Genetically confirmed diagnosis of primary mitochondrial disease (known pathogenic mutation(s) in mitochondrial or nuclear DNA known to cause primary mitochondrial disease) Ptosis Exclusion: Genetic diagnosis not consistent with primary mitochondrial disease. No genetic diagnosis Unable to cooperate with light treatment or ophthalmological assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Palpebral fissure width | 3 months from baseline |
Countries
United Kingdom
Contacts
Primary ContactGlen Jeffery, PhD
Outcome results
None listed