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A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision

In Hospital Treatment of Opioid Use Disorder: Clinician Perspectives and Current Practices

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06291090
Enrollment
400
Registered
2024-03-04
Start date
2023-01-18
Completion date
2025-05-01
Last updated
2026-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid Use Disorder

Keywords

opioid use disorder, hospital

Brief summary

The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD.

Detailed description

The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD. The intervention included nurse driven universal screening for unhealthy substance use with a social work referral for a brief intervention when indicted, electronic health record-embedded protocols to assess for opioid withdrawal and to direct buprenorphine initiation, methadone orders for opioid withdrawal symptoms, and embedded links for post discharge addiction treatment referral. It also included clinician education and nursing education via video conference or in-person lectures. The intervention was supported by the health system Chief Medical Officer and involved subject matters expertise and representation from nursing leaders, social work leaders, and hospital medicine leaders. Outcomes assess include a pre/post implementation assessment of 1) change in buprenorphine prescribed in hospital and 2) discharge, 3) change in naloxone prescribed, 4) change in hospital based methadone prescribing, and 5) change in average clinical opioid withdrawal scale (COWS) score. investigators also assessed a pre/post survey of hospitalists physicians and advanced practice providers to assess their perception of hospital based OUD treatment provision.

Interventions

BEHAVIORALOUD treatment intervention

Participants received education on the diagnosis and management of OUD, have access to protocols to walk them through assessment of OUD using Diagnostic and Statistical Manual, fifth Edition (DSM)-5, COWS score to calculate severity of opioid withdrawal, buprenorphine or methadone initiation with pre-populated orders, and clickable links for OUD treatment referral post discharge.

Sponsors

University of Colorado, Denver
Lead SponsorOTHER
National Institute on Drug Abuse (NIDA)
CollaboratorNIH

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Intervention model description

This intervention will be implemented across 12 hospitals

Eligibility

Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes

Inclusion criteria

* Physicians, advanced practice providers, social workers, and nurses who work at any affiliated hospitals

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frameDescription
Change in buprenorphine prescribing at hospital dischargeCalculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for changeChange in rate of buprenorphine prescribing at hospital discharge among patients with OUD before and after intervention implementation

Secondary

MeasureTime frameDescription
Change in rates of methadone prescribing during hospitalizationCalculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for changeChange in rate of in hospital methadone prescribing among patients with OUD before and after intervention implementation

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORSusan L Calcaterra, MD

University of Colorado, Denver

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026