Infertility, Ovarian Insufficiency
Conditions
Brief summary
Studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality. The utilization of Artificial Oocyte Activation (AOA) is safe and does not increase birth defects, cognition, language and motor skills. AOA is the first line of treatment in patients with globozoospermia (round headed spermatozoa). Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists and comprises about 10-15% of patients undergoing controlled ovarian hyperstimulation. The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. The European Society of Human and REproduction (ESHRE) recommends AOA in cases with failed fertilization/ low fertilization.
Interventions
OTHERwomen having had a second IVF cycle with AOA
The absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. Physiological oocyte activation requires a sperm-derived enzyme called phospholipase C zeta to cause the release of calcium in the form of oscillations from internal storages.
Sponsors
Clinique Ovo
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* Patients with poor or no blastocyst development in their primary cycle * Group 1 - second cycle using AOA following the poor blastocyst development cycle * Group 2 - second cycle without AOA following the poor development cycle
Exclusion criteria
* All cycles who do not have repeat cycles following the poor blastocyst development cycle
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blastocyst rate | 5 days after oocyte fertilization | Likelihood of an oocyte fertilized to blastocyst stage |
Countries
Canada
Outcome results
None listed