Living Donor Liver Transplantations With Anti-HBc (+) Grafts
Conditions
Brief summary
The goal of this observational study is to compare in anti-HBc (+) grafts/ anti-HBc (-) grafts. The main question it aims to answer is the long-term efficacy of active vaccination and graft/patient outcomes of anti-HBc (+) grafts have yet to be comprehensively investigated. Researchers will compare anti-HBc (+) grafts/ anti-HBc (-) to see if it would affect the long-term survival.
Detailed description
A particular strength of the present study is in the inclusion of a consecutive cohort of pediatric LDLT recipients with long-term details of follow-up, although there are several limitations. First, this was a retrospective study conducted at a single medical center. Second, the HBV prophylaxis changed from lamivudine to entecavir in 2008, therefore investigators were unable to evaluate the risk of developing lamivudine resistance. In addition, the DNA level data for the donor and graft tissues were lacking. Lastly, this study was conducted in an area with a high prevalence of anti-HBc positivity.
Interventions
None listed
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
\- consecutive pediatric LDLT recipients.
Exclusion criteria
* Adult LDLT recipients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts | Feb. 2002-Feb.2016 | Investigation of the Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts |
Outcome results
None listed