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Thyroid and Cortisol Hormone Response to Sepsis

Thyroid and Cortisol Hormone Response in Patients With Sepsis Who Attended To Assiut University Hospitals (ICU)

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06289179
Enrollment
114
Registered
2024-03-01
Start date
2024-03-01
Completion date
2026-10-25
Last updated
2024-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Brief summary

Thyroid and cortisol hormone response to sepsis

Detailed description

Sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.

Interventions

None listed

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years

Inclusion criteria

* The study will include Adults (≥18 years), both genders * septic patients admitted to critical care unit

Exclusion criteria

* thyroid disease * hypopituitarism * Addison disease * Cushing syndrome)

Design outcomes

Primary

MeasureTime frameDescription
Pattern of cortisol level and thyroid function response to sepsis in ICUFrom time of admission to ICU up to 3rd day after dischargeAffect of sepsis on hormones at ICU:compare the change of endocrinal hormones ( TSH (mIU/L) .T3(ng/dL) .T4 ( mcg/dL) adrenocorticotropic hormone ACTH (pg/mL) , cortisol (µg/dL)) at time of admission, course ICU ,3rd day after discharge

Contacts

Primary ContactSara Mahmoud khalf allah Mohamed
saramm302@gmail.com01099929480
Backup ContactMohamed Hossam Aldin Hassan, Professor
hossammaghraby@yahoo.com01006261166

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026