Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging

Predicting Prognosis in Subacute Ischemic Stroke Through Brain Perfusion and Collateral Circulation With Multimodal Imaging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06289036

Enrollment

Registered

2024-03-01

Start date

2021-02-01

Completion date

2023-12-31

Last updated

2024-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke

Brief summary

We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale \[mRS\] ≤ 2) and poor prognosis (mRS \> 2).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 88 Years

Healthy volunteers

Inclusion criteria

1. Confirmed unilateral internal carotid artery/MCA atherosclerotic stenosis/occlusion with a stenosis degree \> 50% verified through computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA). 2. Presence of IS or transient ischemic attack (TIA) symptoms in the circulating blood supply area within the preceding 48 h. 3. Asymptomatic patients with no history of IS or TIA in the past 6 months. 4. Performance of 4D ASL tests during hospitalization.

Exclusion criteria

1. Moderate-to-severe stenosis/occlusion of the contralateral internal carotid artery/middle cerebral arteries. 2. Age ≤ 18 years old. 3. Cardioembolic cerebral infarction. 4. Moyamoya disease. 5. Combined or previous cerebral hemorrhage or subarachnoid hemorrhage 6. History of previous cerebral infarction. 7. Claustrophobia or the presence of intracranial metal implants, cochlear implants, or pacemakers.

Design outcomes

Primary

Measure	Time frame	Description
Modified Rankin Scale（mRS） score after 3 months of onset	3 months	mRS scores range from 0 to 6, where 0 indicates no symptoms, 3 indicates moderate disability, 4 indicates moderately severe disability, 5 indicates severe disability, and 6 indicates death. Patients were categorized into a good prognosis group (mRS ≤ 2) and a poor prognosis group (mRS \> 2).

Countries

China

Outcome results