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Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Efficacy of Olanzapine on Weight Gain in Women with Advanced Stage Gynecologic Cancer Receiving Paclitaxel and Carboplatin Combination Chemotherapy : a Double Blind, Placebo-controlled Randomized Trial

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06288854
Enrollment
48
Registered
2024-03-01
Start date
2024-04-03
Completion date
2025-06-30
Last updated
2024-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Weight Gain

Brief summary

* Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer * Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Detailed description

-Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Interventions

OTHERweight gain each group

weight gain after 12 Weeks

Sponsors

Department of Medical Services Ministry of Public Health of Thailand
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Intervention model description

olanzapine vs placebo

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy * ECOG 0-1 * Normal CBC,Liver, renal function * Communication in Thai language or Thai caregiver * Inform consent

Exclusion criteria

* Pregnancy * Active infection * Bowel obstruction or history of bowel surgery * On dopamine receptor antagonists or psychiatric or anticonvulsant medication * Olanzapine allery * Abnormal function of liver and renal * Diabetic melitus or morbid obesity * patient can't selfcare

Design outcomes

Primary

MeasureTime frameDescription
Efficacy of olanzapine on weight gain in advanzed stage gynecologic cancer recieving paclitexal and carboplatin chemotherapy12 weeks after interventionproprotion of pateints gain weight after intervention (olanzapine or placebo) by monitor weight before and after get intervention

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026