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Oral Fluid vs IV Fluid After Primary TKA

Comparison Efficacy of Oral Fluid Versus Intravenous Fluid Replacement in Postoperative Primary Total Knee Arthroplasty : A Randomized Controlled Trial.

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06288815
Enrollment
130
Registered
2024-03-01
Start date
2024-01-10
Completion date
2025-06-30
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Fluid Replacement, Osteoarthritis, Knee, Total Knee Arthroplasty

Brief summary

The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty. The main question it aims to answer is: Does oral fluid replacement after primary unilateral total knee arthroplasty provide a patient recover faster than intravenous fluids replacement?

Interventions

DIETARY_SUPPLEMENTOral fluid

Postoperation * Off IV fluid immediately postoperative * Allow patients drink oral fluid as protocol for 24hr

DIETARY_SUPPLEMENTIV fluid

Postoperation * IV fluid replacement as protocol for 24hr * Allow patients drink oral fluid as usual

Sponsors

Thammasat University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

* Age 40-85 years old * ASA I, II * Primary osteoarthritis

Exclusion criteria

* Diuretics use * Morbid obesity * Previous knee surgery * Cannot undergo spinal anesthesia

Design outcomes

Primary

MeasureTime frameDescription
Time to stand and walkPostoperative day 1Stand and walk with walker

Secondary

MeasureTime frameDescription
Incidence of oliguriaPostoperative day 1,2Urine output \< 0.5ml/kg/hr
Incidence of nausea/vomitingPostoperative day 1,2record symptom of nausea and vomiting
Urine specific gravityPostoperative day 1Urine specific gravity every 4 hours
Time up and go24 and 48 hoursRecord time since stand up and walk 3 meters, or 10 feet away, on the floor
the levels of creatininePostoperative day 1,2Blood chemistry
the levels of blood urea nitrogen (BUN).Postoperative day 1,2Blood chemistry
ComplicationsUntil postoperative 3monthsPulmonary edema, heart failure, acute kidney injury
the levels of certain electrolytesPostoperative day 1,2Blood chemistry

Countries

Thailand

Contacts

Primary ContactYot Tanariyakul, M.D.
y.tanariyakul@gmail.com663930257

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026