Dry Eye, MGD-Meibomian Gland Dysfunction
Conditions
Brief summary
Renal anemia refers to anemia in which the absolute or relative production of erythropoietin (EPO) is insufficient due to various kidney diseases, and uremic toxins affect erythropoietin production and its lifespan. Common treatment drugs for renal anemia include erythropoietin EPO and Roxadustat (FG-4592). Medical history information was collected from patients with renal anemia who visited the ophthalmology department with dry eye symptoms. This study will help to determine the function and morphological characteristics of meibomian gland in patients with renal anemia
Detailed description
1. Collect medical records of patients with renal anemia who visited the ophthalmology outpatient department of Zhongnan Hospital and hospitalized patients with renal anemia 2. Patients were divided into Rosallistat group, and EPO group according to their drug use history. 3. The dry eye analysis results of all patients were collected, and the lacrimal river height, tear film rupture time and meibomian gland grade were counted. The results of dry eye examination were analyzed statistically. 4. Complete data collection, conduct statistical analysis, and evaluate the analysis results.
Interventions
DIAGNOSTIC_TESTDry eye examination
1. Lacrimal river height 2. tear break-up time 3. tear-film lipid layer thickness 4. meibomian glands two-dimensional digital infrared images
Sponsors
Zhongnan Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* long-term use of Roxadustat or erythropoietin for renal anemia
Exclusion criteria
* contact lens wearer, history of eye surgeries, systemic health conditions affecting ocular health and those who were unable to cooperate with examinations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lacrimal river height | Immediately and six months later | Measured by dry eye analyzer machine |
| tear break-up time | Immediately and six months later | Measured by dry eye analyzer machine |
| tear-film lipid layer thickness | Immediately and six months later | Measured by dry eye analyzer machine |
| meibomian glands two-dimensional digital infrared images | Immediately and six months later | Measured by dry eye analyzer |
Countries
China
Outcome results
None listed