Young-onset Dementia
Conditions
Brief summary
The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to * Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls. * Examine if there is a relation between social cognition tests and measures of risky behaviour. Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.
Interventions
OTHERNeuropsychological assessment, driving simulator task
Neuropsychological assessment consisting of test measuring general cognitive abilities and social cognition. Driving simulator task measuring risk-taking.
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
University Medical Center Groningen
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
All subjects * Sufficient command of the Dutch language * In possession of a driver's license with any driving experience throughout life * Age 18 to 65 bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * Nosological diagnosis of bvFTD or bvAD Non-bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD. Frontal brain injury subjects \- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients).
Exclusion criteria
All subjects * Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness YOD subjects: \- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia. Frontal brain injury subjects: \- Presence of serious psychiatric disorders or other neurological comorbidities. Healthy control subjects: * Presence of serious psychiatric disorders * History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Social cognitive performance | 2024-2027 | Social cognition in bvYOD, compared to non-bvYOD, patients with frontal brain injury and healthy controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between social cognition and risky decision-making | 2024-2027 | Association between several aspect of social cognition (i.e. emotion recognition, empathy, theory of mind, emotion experience) and risk-taking behaviour. |
Contacts
Primary ContactGelmers
Outcome results
None listed