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Complications of High Frequency Jet Ventilation

Complications of High Frequency Jet Ventilation During Bronchoscopy - a Retrospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06285994
Enrollment
1385
Registered
2024-02-29
Start date
2024-03-03
Completion date
2025-02-01
Last updated
2025-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-Frequency Jet Ventilation, Bronchoscopy

Brief summary

High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as: * Hypoxia: SpO2 \< 90% for 1 min * Severe hypoxia: SpO2 \< 85% for 1 min * Hemodynamic instability, defined as Arterial pressure \< 90/60 * Cardiac arrhythmia * Laryngospasm or bronchospasm * Barotrauma or volutrauma * Need for ICU admission A model predicting the risk for developing any complication will be developped using 2 mathematical methods: * a multivariate analysis * a data mining approach For both approaches, the following variables will be included in the model: * Age * Gender * Weight * Height * BMI * Smoking * Alcohol consumption * Consumption of Other drugs * ASA class * Obstructive pulmonary disease * Restrictive lung disease * COPD status (1, 2, 3, 4) * Interstitial lung disease * Lung tumor * Trachea location * Carina location * Bronchial location * Pulmonary or tracheal stenosis * Presence of stridor * Severe stenosis (\< 6 mm) * Baseline SpO2 (pre-intervention) * Pre-intervention oxygen requirement Procedure * Duration (min) * Stent placement * Dilation * Laser treatment * Length of hospital stay Lung function tests * FEV1 (forced expiratory volume) * VC (Vital Capacity) * FEV1/VC (Tiffeneau ratio) * CPT (total lung capacity) * DLCO (carbon monoxide diffusion)

Interventions

Use of high frequency jet ventilation during bronchoscopy

Sponsors

Erasme University Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels

Exclusion criteria

* Incomplete medical chart * Patient who expressed their opposition to the use of their medical data

Design outcomes

Primary

MeasureTime frameDescription
Occurence of complications6 hoursThe occurence (%) of complications of HFJV will be analyzed. Definition of complications is one or more of the following events: * Hypoxia: SpO2 \< 90% for 1 min (%) * Severe hypoxia: SpO2 \< 85% for 1 min (%) * Hemodynamic instability, defined as Arterial pressure \< 90/60 (%) * Cardiac arrhythmia (%) * Laryngospasm or bronchospasm (%) * Barotrauma or volutrauma (%) * Need for ICU admission (%) Complications will be reported as overall complications (%) defined as the occurence of one or more of the listed events. Frequency of single events will be reported separately (%). Descriptive statistics ( %, mean, standard deviation, median, interquartile range) will be used as appropriate.

Secondary

MeasureTime frameDescription
Prediction model of complications6 hoursA model predicting the risk for developing any complication will be developped using 2 mathematical methods: * a multivariate analysis * a data mining approach

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 3, 2026