Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

Analgesia Nociception Index and Autonomic Nervous System Exploration During Continuous Renal Replacement Therapy in Intensive Care Patients.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06285162

Acronym

UFANI

Enrollment

Registered

2024-02-29

Start date

2026-01-09

Completion date

2027-04-30

Last updated

2026-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically Ill, Renal Replacement Therapy

Keywords

Analgesia Nociception Index, R-R interval, autonomic nervous system, haemodynamic, fluid removal

Brief summary

The Analgesia Nociception Index (ANI) reflects the balance between sympathetic and parasympathetic tone. It is based on a specific interpretation of the R-R interval variation. During fluid removal by net ultrafiltration in patients with fluid overload and continuous renal replacement therapy, some data suggest that haemodynamic variation could be induced by the autonomic nervous system. The study aims to investigate ANI variations in this context and their association with the haemodynamic variations observed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Continuous renal replacement therapy in intensive care unit * Initiation of net ultrafiltration according to the protocol of the department or to EARLYDRY study (NCT 05817539) (3 criteria required): * Fluid overload \> 5% or peripheral oedema * Noradrenaline equivalent \<0.5μg/kg/min * No peripheral hypoperfusion * Invasive blood pressure monitoring * Central venous line in superior vena cava territory * Regular sinus rhythm * Patient awake or Richmond Agitation and Sedation Scale \> -3

Exclusion criteria

* Ongoing administration of inotropes * Ongoing administration of beta blockers * Current administration of alpha-2 agonists * History of dysautonomia * Pregnant or breast-feeding woman * Mechanical circulatory assistance * Opposition to participate * Adults under legal protection * Persons deprived of their liberty by judicial or administrative decision

Design outcomes

Primary

Measure	Time frame	Description
Percentage of changes in ANI.	6 hours after initiation of net ultrafiltration	Relative changes in ANI (averaged over 4 minutes (percentage)) between Hour 0 and Hour 6 of initiation of net ultrafiltration.

Countries

France

Contacts

Primary ContactMartin RUSTE, MD

martin.ruste@chu-lyon.fr+33472118956

Outcome results