Alcohol Use Disorder
Conditions
Brief summary
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question\[s\] this trial aims to answer are: Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues? Will high-intensity EFT cues effect greater treatment-seeking interest? Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity) Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS? Will the novel behavioral SS decision-making task activate the nucleus accumbens? Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.
Interventions
BEHAVIORALHigh-Intensity Cue
Participants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.
BEHAVIORALLow-Intensity Cue
Participants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.
Sponsors
Indiana University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Eligible participants will be randomly assigned to either the high-intensity (experimental) or low-intensity (control) groups.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Abstinence between 30 days ≤ 1 year * Verbal endorsement of commitment to recovery * English comprehension
Exclusion criteria
* Unstable medical disorders * Outside the age range of 18-60 * Habitual substance or alcohol use * Smell/taste disorders * Unstable psychiatric conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Increase Prospective Thinking | [Time Frame: Study Day Visit (Day 1)] | High-intensity episodic future-thinking image cues will increase prospective thinking. |
| Delayed Rewards | [Time Frame: Study Day Visit (Day 1)] | High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORBrandon G Oberlin, PhD
Indiana University
Outcome results
None listed