Benign Prostatic Hyperplasia
Conditions
Keywords
Benigh Prostate Hyperplasia(BPH), Urine Growth Factors
Brief summary
The Changes of Urine Growth Factors Level in Patients With Benigh Prostate Hyperplasia after medical treatment.
Detailed description
The prevalence of benign prostate hyperplasia, like medical illness such as hypertension, diabetes mellitus and stroke, increase by age. Benign prostate hyperplasia will cause bothersome lower urinary tract symptoms in the middle and aged male. Previous studies have showed that overactive bladder syndrome (urge, frequency, nocturia or urinary incontinence) has been considered as an important factor to predict successful treatment. Urine nerve growth factor level, brain-derived neurotrophic factor and endothelium vascular growth factor have been proved as a simple and noninvasive biomarker for diagnosing overactive bladder. As a result, investigator will investigate the changes of these growth factors level in patients with benign prostate hyperplasia before and after three and six-months medical treatment. In addition, investigator can understand whether overactive bladder will have effects on successful medical treatment in patients with benign prostate hyperplasia.
Interventions
DRUGSilodosin
Indications:Benign prostate hyperplasia
Sponsors
En Chu Kong Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* men with age 50\ 80 years old * IPSS\>12 * maximal flowrate 5\ 15ml/sec * prostate size\>20ml * urine amount\>150ml * patient/family can sigh the inform concent
Exclusion criteria
* prostate cancer or suspected prostate cancer(PSA\>4ng/ml) * history of prostate surgery * free of active urinary tract infection in past 6 months * patient with any other serious disease considered by investigator not in the condition to enter trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine growth factors level | One month after medical treatment | Check Urine growth factors level after one month |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Urine growth factors level | Three months after medical treatment | Check Urine growth factors level afterthree month |
Other
| Measure | Time frame | Description |
|---|---|---|
| Urine growth factors level | Six months after medical treatment | Check Urine growth factors level after si xmonth |
Countries
Taiwan
Outcome results
None listed