Carpal Tunnel Syndrome, Vitamin D Deficiency
Conditions
Keywords
Carpal Tunnel Syndrome, Vitamin D Deficiency, Electrophysiologia
Brief summary
Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels.
Detailed description
Introduction: Apart from its effect on bone health, vitamin D is also known to have beneficial effects on the neurological system. In studies, vitamin D levels were found to be low in patients with Carpal Tunnel Syndrome (CTS). However, studies examining the effects of vitamin D replacement on CTS are limited. Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels. Materials and Methods: Our study was planned as an observational and analytical prospective. Vitamin D loading therapy was given to patients with serum vitamin D levels below 20ng/ml and mild-moderate CTS detected by electroneuromyography (ENMG). Patients with vitamin D levels above 20 ng/ml after 8 weeks were included in the study. Each patient was given a rest splint and exercise program. Patients were evaluated before and 3 months after treatment with electrophysiological, ultrasonographic, VAS, pinch-grip strength, two-point discrimination, monofilament test and Boston symptom severity scale.
Interventions
DRUGVitamin D
Vitamin D replacement therapy was administered at 50,000 IU weekly for 8 weeks.
Sponsors
Kayseri City Hospital
Dr. Ayşe Güç
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 18-70 years old male or female gender * Those with mild to moderate CTS according to ENMG, * Vitamin D level \<20.
Exclusion criteria
* Severe CTS according to ENMG * Thenar region atrophy * diabetes mellitus, * rheumatoid arthritis, * hyperthyroidism, * hypothyroidism * Traumatic nerve injury, history of surgery * Polyneuropathy * Pregnancy * Severe psychiatric illness * Poor orientation and cooperation, * Injection (corticosteroid, ozone, stem cell…) applied for CTS treatment within 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| electrophysiological scale. | at the baseline and immediately after treatment | Electrophysiological Evaluation: Neurowerk (SIGMA-Medizin-TechnicGmbH/Germany) brand ENMG device was used. Patients were evaluated at room temperature of approximately 25 °C. All measurements were made by the same doctor. Our clinic's reference values for the diagnosis of CTS are shown below |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| monofilament test | at the baseline and immediately after treatment | Semmes-Weinstein monofilament test (SWMT): The first three fingertips on the palmar surface of the hand included with the 6-monofilament set of Baseline company were evaluated. Monofilament number 2.83 was taken as the threshold value for normal sensory value. SWMT was applied blindly by the same occupational therapist who was unaware of the patients' disease and the treatment they received. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Boston symptom severity scale | at the baseline and immediately after treatment | Boston Carpal Tunnel Syndrome Questionnaire (BCTSQ): The questionnaire consists of two parts. Boston Symptom Severity Scale (BSSS), which questions the severity of symptoms, consists of 11 questions. Boston Functional Status Scale (BFSS), which evaluates functional capacity, consists of 8 questions. The degree of difficulty of symptoms and functional activity increases towards 5 points. |
Countries
Turkey (Türkiye)
Outcome results
None listed