Mild Cognitive Impairment, Subjective Cognitive Decline
Conditions
Keywords
Subjective Cognitive Decline, Mild Cognitive Impairment, Cognitive enhancement, Board games
Brief summary
The goal of this clinical trial\]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline. The main questions it aims to answer are: * Do Go and Chess improve cognition? * Is a game better than the other? Is the effect of both games on cognition synergistic? * Do Go and Chess improve quality of life? * Do Go and Chess improve mood? * Do Go and Chess improve lifestyle? Participants will be randomized to one of four groups: * Group intervention with Go, once a week, for 12 weeks * Group intervention with Chess, once a week, for 12 weeks * Group intervention with Go and Chess, twice a week, for 12 weeks * Control group
Interventions
OTHERGo classes
Classes of board games (Go), performed in groups of 6-10 subjects, once a week
OTHERChess classes
Classes of board games (Chess), performed in groups of 6-10 subjects, once a week
Sponsors
University of Milano Bicocca
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of mild cognitive impairment or subjective cognitive decline * Willingness to participate in the board games classes * Living within 20-minute driving distance from the center * Signed informed consent
Exclusion criteria
* Prior knowledge of the the game rules (in case the subject knows one of the two, they can be randomized to the other one) * Significant linguistic or sensory impairment (according to clinical judgment) * Significant behavioral or psychiatric disturbances (according to clinical judgment) * Significant medical comorbidities (according to clinical judgment)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| General cognition | 12 weeks | Differences in Montreal Cognitive Assessment between groups \[continuous scale, 0-30, higher scores indicate better performances\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Digit Span Forward | 12 weeks | Differences in Digit Span Forward between groups \[continuous scale, 0-9, higher scores indicate better performances\] |
| Digit Span Backwards | 12 weeks | Differences in Digit Span Backwards between groups \[continuous scale, 0-9, higher scores indicate better performances\] |
| Trail Making Test - part A | 12 weeks | Differences in Trail Making Test - part A between groups \[time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances\] |
| Trail Making Test - part B | 12 weeks | Differences in Trail Making Test - part B between groups \[time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances\] |
| Semantic fluency | 12 weeks | Differences in Semantic fluency between groups \[continuous scale, min 0, max N/A, higher scores indicate better performances\] |
| Quality of life indicator | 12 weeks | Differences in WHO Quality of life (WHO-QoL) scale between groups \[continuous scale, min 0 max 100, higher scores indicate better quality of life\] |
| Depression | 12 weeks | Differences in geriatric depression scale scale between groups \[continuous scale, min 0 max 15, higher scores indicate worse depression\] |
| Lifestyle | 12 weeks | Differences in simple lifestyle indicator questionnaire scale between groups \[continuous scale, min 0 max 10, higher scores indicate healthier lifestyle\] |
Countries
Italy
Contacts
PRINCIPAL_INVESTIGATORLucio Tremolizzo, MD, PhD
Fondazione IRCCS San Gerardo
Outcome results
None listed