Uveal Melanoma
Conditions
Brief summary
The purpose of this study is to evaluate the incidence and severity of retinopathy and opticopathy one year after treatment with hypofractionated stereotactic photon radiotherapy due to uveal melanoma. Patients will be imaged before radiation, as well as 3, 6, 9 and 12 months after radiation using sonography funds photography, optical coherence tomography angiography, oximeter and microperimetry.
Interventions
DIAGNOSTIC_TESTClinical examination and multimodal ocular imaging
Imaging consists of sonography, fundus photography, oximeter, optical coherence tomography angiography, and Microperimetry.
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with newly diagnosed uveal melanoma, who will be treated with hypofractionated stereotactic photon radiotherapy as part of clinical routine.
Exclusion criteria
* unwillingness to participate in the study * severe media opacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence and Severity of Retinopathy | 1 year | Incidence and severity of retinopathy will be evaluated as non-perfusion areas on optical coherence tomography angiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence and Severity of Opticopathy | 1 year | Incidence and severity of retinopathy will be evaluated on clinical examination and fundus photography |
| Functional Outcome | 1 year | Functional outcome will be evaluated as mean retinal sensitivity. |
| Incidence and Severity of Retinopathy and Opticopathy in oximeter | 1 year | Incidence and severity of retinopathy and opticopathy will be evaluated using oxygen saturation |
Countries
Austria
Contacts
Primary ContactJudith Kreminger, MD
Backup ContactReinhard Told, MD, PhD
Outcome results
None listed