Exosome, Laser, Skin Regeneration
Conditions
Keywords
Exosome, Q-switched laser
Brief summary
the goal of this half-face controlled study is to evaluate the effect of exosome-containing liquid dressings on the recovery of patients after Nd:YAG laser 532 treatment.
Detailed description
The main objective was to collect patients with fleae or seborrheic keratosis after Q-switched laser treatment, and then to use exosomes or matrix on both sides of the face, and finally to evaluate the effect of exosomes on wound healing and prevention of post-inflammatory hyperpigmentation after Nd:YAG laser 532 treatment
Interventions
DRUGExosome liquid dressing
This study mainly adopted a randomized double-blind self-half face control method. The double-blind method was that the subjects and researchers did not know the experimental group and the control group. 38 sets of matched use sets (left and right, only the manufacturer knew the specific ingredients) were respectively applied to both sides of the cheeks of patients after Q-switched laser. The blind was unblinded after the experiment.
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* It meets the diagnostic criteria of seborrheic keratosis or freckle； * pepole are able to follow the treatment rules of the study and were followed up for 8 weeks； * informed consent
Exclusion criteria
* History of keloids ; * Pregnancy or lactation; * Any cosmetics containing growth factor-related ingredients used within 6 months prior to treatment * Patients with incomplete observation data and incomplete course of treatment were excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global Aesthetic Improvement Scale score | 1, 3.5, 7, 14, 28, and 56 days | The treating physician evaluated the patient's improvement, which was divided into four levels: very improved corresponding, substantial improvement, improvement, no change; Corresponding to the best beauty results, significantly improved but not the best, significantly improved, no change |
| Dermatology Quality of life index | 1, 3.5, 7, 14, 28, and 56 days | By answering multiple questions, patients self-rated the impact of their current illness on their lives within a week and scored. The answers were graded on four levels, very serious 3, very serious 2, a little 1, and no 0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| post-inflammatory hyperpigmentation | 2.4,8 weeks | At 2, 4 and 8 weeks of follow-up, melanin index was measured by memetreter (memetreter MX18 cuttometer Dual MPA580, EnviroDerm Services (UK) Ltd) at the same follow-up. Objective evaluation of PIH. |
Countries
China
Contacts
Primary Contactjie Dai
Outcome results
None listed