Meningioma
Conditions
Keywords
Meningioma, Hormonal receptors
Brief summary
This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.
Exclusion criteria
* Patients who did not express their consent to participate in the study. * Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study. * Patients with grade 1 meningiomas not selected by randomization. * Patients withdrawing their consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| immunohistochemical expression of different hormonal receptors | up to 24 years after surgery | Evaluated on FFPE sections |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| methylation profile of the promoters of hormonal receptor genes | up to 24 years after surgery | Methylation profile established from frozen tissue. |
Outcome results
None listed