Cachexia
Conditions
Brief summary
Gastric cancer is one of the most common malignancies, the morbidity and mortality of which are among the highest. In cancer patients, the incidence of cachexia is very high, and even 80% of patients will eventually develop into cachexia. However, once gastric cancer patients develop cachexia, patients are unlikely to obtain clinically significant benefits from conventional treatment. Therefore, it is important to find biomarkers for early detection of cachexia. The investigators carried out a plasma-derived exosomal microRNA(miRNA) study for early diagnosis of cachexia in gastric cancer, and the development of early diagnosis kits for gastric cancer cachexia.
Detailed description
Gastric cancer is one of the most common malignancies, the morbidity and mortality of which are among the highest. In gastric cancer patients, the incidence of cachexia is very high, and even 80% of patients will eventually develop into cachexia. However, once gastric cancer patients develop cachexia, patients are unlikely to obtain clinically significant benefits from conventional treatment. Therefore, it is important to find biomarkers for early detection of cachexia. The investigators carried out a plasma-derived exosomal microRNA(miRNA) study for early diagnosis of cachexia in gastric cancer, and the development of early diagnosis kits for gastric cancer cachexia.
Interventions
OTHERcachexia
Cachexia mainly manifests as weight loss. 1)weight loss \>5% over past 6 months. 2)BMI\<20 and any degree of weight loss \>2%. 3)Appendicular skeletal muscle index consistent with sarcopenia and any degree of weight loss \>2%.
Sponsors
Xijing Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with gastric cancer diagnosed by histopathology or cytopathology 2. Complete clinical and pathological data 3. No previous or current mental illness or disturbance of consciousness
Exclusion criteria
1. With multiple tumors or other malignant diseases 2. Combined with other chronic wasting and metabolic diseases 3. Past patients with non-tumor cachexia 4. People with mental illness or unable to cooperate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BMI | six months | Calculate BMI based on changes in body weight in the past six months |
Countries
China
Contacts
Primary ContactJipeng Li
Outcome results
None listed