Attention Deficit Hyperactivity Disorders, Developmental Delays
Conditions
Keywords
preschool children, developmental delay, cognitive training, attention deficit hyperactivity disorder
Brief summary
To explore whether children with Attention Deficit Hyperactivity Disorder and developmental delays who receive cognitive training and conventional rehabilitation can improve executive function more than traditional rehabilitation alone. A magnetoencephalographic examination will be arranged to explore how brain network activation works. Research method: 20 preschool children with Attention Deficit Hyperactivity Disorder and developmental delays under rehabilitation therapy will be collected. They will be randomly assigned to the experimental group (receiving rehabilitation therapy and three times per week for 15 minutes, a total of 12 weeks of interactive cognitive training) and the control group (receiving rehabilitation therapy only). Therapeutic effects will be evaluated.
Detailed description
Research method: 20 preschool children with Attention Deficit Hyperactivity Disorder and developmental delays under rehabilitation therapy will be collected. They will be randomly assigned to the experimental group (receiving rehabilitation therapy and three times per week for 15 minutes, a total of 12 weeks of interactive cognitive training) and the control group (receiving rehabilitation therapy only). Therapeutic effects will be evaluated, including Sensory Profile, Swanson, Nolan and Pelham version IV, Conners Kiddie Continuous Performance test, Chinese Childhood Executive Functioning Inventory, and Chinese version of Wechsler Intelligence Scale for Children-IV; and physical health conditions, including Pediatric Daily Occupation Scale, Pediatric Outcome Data Collection Instrument (PODCI), Child Health Questionnaire- Parent Form, Pediatric Quality of Life Inventory (PedsQL)will be evaluated by an investigator who is blinded to the group's allocation at before treatment and after 12 weeks of treatment. All participants will be investigated by magnetoencephalography (MEG) to identify the brain network connectivity while performing different tasks before and after 12 weeks of treatment. Brain Magnetic Resonance Imaging will be performed for brain mapping. Possible results: The study will shed light on therapeutic effects and brain network connectivity by cognitive training for preschool children with Attention Deficit Hyperactivity Disorder and developmental delays.
Interventions
OTHERcognitive training
cognitive training, 15 min, three times per week, for 12 weeks
OTHERactive control
Traditional rehabilitation programs
Sponsors
Taipei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome measurements will be performed by a researcher who is blind to the groups' allocation.
Intervention model description
Twenty preschool children with Attention Deficit Hyperactivity Disorder and developmental delays under rehabilitation therapy will be collected. They will be randomly assigned to the experimental group (receiving rehabilitation therapy and three times per week for 15 minutes, a total of 12 weeks of interactive cognitive training) and the control group (receiving rehabilitation therapy only). Therapeutic effects will be evaluated by an investigator blinded to the group's allocation before and after 12 weeks of treatment.
Eligibility
Sex/Gender
ALL
Age
4 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* preschool children with Attention Deficit Hyperactivity Disorder and developmental delays under regular rehabilitation programs intelligence quotient 70 or greater
Exclusion criteria
* age less than 4 or greater than 6 metal in teeth intelligence quotient less than 70
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of executive function | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by the Taiwanese Traditional Chinese Childhood Executive Functioning Inventory range from 1 to 5, higher scores indicate a worse outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes of symptoms of attention deficit hyperactivity disorder | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Swanson, Nolan and Pelham questionnaire, range from 0 to 54, higher scores indicate a worse outcome |
| changes of attention | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Conners Kiddie Continous Performance Test, range from 0-100, higher scores indicate a worse outcome |
| Changes of sensory integration | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Sensory Profile, range from 0-100, higher scores indicate a better outcome |
| changes of intelligence | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by the Wechsler Intelligence Scale of children, the average score is 100, with a higher score indicating higher intelligence and a lower score indicating a lower level of intelligence. |
| Changes of family impact | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Child Health Questionaire, parent form 28, range from 0-100, higher scores indicate a better outcome |
| Changes of quality of life | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Pediatric Quality of Life Inventory, range from 0-100, higher scores indicate a better outcome |
| Changes in performance activity in kindergarten | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Kindergarten Performance Activity, range from 0-100, higher scores indicate a worse outcome |
| changes of functional performance | score change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes in scores assessed by Pediatric Outcome Data Collection Instrument, range from 0-100, higher scores indicate a better outcome |
Other
| Measure | Time frame | Description |
|---|---|---|
| changes of brain network connectivity | connectivity change from baseline to 12 weeks of treatment, higher score, the better outcome | Changes of brain network connectivity assessed by magnetoencephalography, range from 0-1, higher scores indicate a better outcome |
Countries
Taiwan
Contacts
Primary ContactRu-Lan Hsieh, MD, MD
Backup ContactRu-Lan Hsieh, MD, MD
Outcome results
None listed