The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial

The Effect of Using Desensitizers Containing S-PRG Versus Sodium Fluoride With Functionalized Tri-Calcium Phosphate In Treatment Of Dentin Hypersensitivity In Adult Patients Over 6 Months: A Randomized Clinical Trial

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06276777

Acronym

S-PRG

Enrollment

Registered

2024-02-26

Start date

2024-05-01

Completion date

2024-12-01

Last updated

2024-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Hypersensitivity

Keywords

S-PRG

Brief summary

The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal hypersensitivity in adult patients for six months follow-up. patients will be asked to report pain degree on the visual analogue scale (VAS) along the follow up periods on both groups.

Interventions

PROCEDURETooth varnish (PRG Barrier Coat from Shofu)

Treatment of cervical dentin hypersensitivity with tooth desensitizers.

PROCEDURETooth varnish (Clinpro white varnish 3M)

Treatment of cervical dentin hypersensitivity with tooth desensitizers.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Masking description

Participants and both assessors will be blind to the type of material used.

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Good oral hygiene. * Cooperative patients who show interest to participate in the study and welling to sign the informed consent. * Healthy patients with no history of previous systematic diseases that can affect their oral health. * Normal and healthy gingival tissue. * Teeth that have no cavitation or restorations. * Patients with at least 20 natural permanent teeth and at least two teeth with a VAS score from 4 to 10. * Anterior teeth.

Exclusion criteria

* Allergic to the ingredients used in the study. * Gastrointestinal disorders (They have repeated vomiting attacks). * Medically compromised (They cannot tolerate the procedures). * Taking desensitizing treatment in the last 6 months (It affects the outcome). * Taking anti-inflammatory drugs (It affects the hypersensitivity perception). * Pregnant females (They complain from nausea and repeated vomiting attacks) * Smokers (Smoking will affect the oral hygiene and periodontal health).

Design outcomes

Primary

Measure	Time frame	Description
Dentin hypersensitivity reduction	assessment will be done immediately after the treatment then after 1 week, 4 weeks, 3 months and 6 months.	The participants will point out the degree of sensitivity on the VAS scale (0-10) chart.

Countries

Egypt

Contacts

Primary ContactEman Omar El-farouk, masters

eman.omar@dentistry.cu.edu.eg01156677558

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026