Blood Vessel Disease, Muscle Edema
Conditions
Brief summary
The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.
Detailed description
Thirty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), SC BFR, and MC BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). The exercise trial will consist of sets of dumbbell wall squats performed to failure with a 2-seconds concentric and 2-seconds eccentric cadence, at 20% of their 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the main effects of treatment and treatment-order interaction on pulse wave velocity, muscle cross-sectional area, and perceptual response.
Interventions
DEVICEDelfi
Cuffs will be worn throughout the entire training session. Training session consist of lower intensity wall squats. Four sets of wall squats will be performed to failure. Arterial stiffness and muscle morphological assessments will be conducted before and after the exercise.
Sponsors
Salisbury University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
Unable to blind due to differences in cuff size and appearance.
Intervention model description
Participants will undergo three treatment sessions (control (no BFR), SC BFR, and MC BFR) in a randomized order separated by one week.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Physically active (\> 1,000 MET/min/wk) for at least six months. 2. Weight stable for previous 6 months (+/-2.5 kg) 3. Female subjects only- reported regular menstrual cycles for the last 2 years
Exclusion criteria
1. BP\>140/90 mmHg 2. BMI\>40 kg/m2 3. Diabetes 4. Familial hypercholesterolemia 5. Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject. 6. Women must not be pregnant, plan to become pregnant during the study, or be nursing 7. Active renal or liver disease 8. All medications and supplements that influence dependent variables\* 9. Recent surgery \< 2 months 10. Alcohol abuse 11. Sleep apnea 12. Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial Stiffness | Prior to and 10-minutes after the exercise intervention | A measurement of vascular health. |
| Muscle Morphology | Prior to and immediately after the exercise intervention | A measurement of vastus lateralis cross sectional area |
Countries
United States
Outcome results
None listed