Cervical Cancer, Cervical Lesion, China, Neuroendocrine Neoplasm, Women
Conditions
Brief summary
The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.
Detailed description
1\. The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis. (1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients. 2\. Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.
Interventions
None listed
Sponsors
Fujian Maternity and Child Health Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
1. Patients diagnosed with cervical neuroendocrine carcinoma by histopathology 2. Clinical data were complete
Exclusion criteria
1. Patients who are not being treated in our hospital 2. Patients with lack of follow-up data, unable to obtain survival information 3. Patients call to refuse to participate in this project 4. The quality of paraffin specimens can not meet the requirements of proteome concentration determination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mortality rate | Among patients with cervical neuroendocrine carcinoma, the mortality rate within 3 years following surgery | 3-year mortality rate for cervical neuroendocrine carcinoma |
| Disease-free survival | Among patients with cervical neuroendocrine carcinoma, the disease-free survival within 3 years following surgery | 3-year disease-free survival for cervical neuroendocrine carcinoma |
Countries
China
Contacts
Primary ContactBinhua Dong
Backup ContactPengming Sun
Outcome results
None listed