Hypospadias
Conditions
Keywords
Hypospadias, platelet rich plasma, distal penile hypospadias
Brief summary
To compare the outcome of applying autologous platelet-rich plasma membrane layer and dartos fascial flap versus only dartos fascial flap in mid and distal penile hypospadias surgery. A total of 220 patients fulfilling the selection criteria were admitted after taking informed consent. Cases were randomly divided into groups A and B using a random generator of the Excel program. In group A, dartos flap and PRP sheet layer were applied and in group B, only a preputial dartos fascial flap was applied
Detailed description
Objective To compare the outcome of application of autologous platelet-rich plasma membrane layer and dartos fascial flap versus only dartos fascial flap in mid and distal penile hypospadias surgery. Methods This randomized controlled trial was conducted at Pediatric General surgical department, the Children's hospital and the University of Child health, Lahore for the period of 12 months. Non probability, purposive sampling was used for data collection and randomization was done to assign the treatment. Total of 220 patients fulfilling the selection criteria were admitted after taking an informed consent. Cases were randomly divided into two groups A and B using random generator of Excel program. In group-A, dartos flap and PRP sheet layer was applied and in group-B, only a preputial dartos fascial flap was applied.
Interventions
OTHERPRP layer
platelet rich plasma layer was applied in addition to dartos flap
OTHERdartos flap
dartos flap alone was used
Sponsors
Children Hospital and Institute of Child Health, Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
randomized control trial
Eligibility
Sex/Gender
MALE
Age
6 Months to 12 Years
Healthy volunteers
No
Inclusion criteria
* patients (Age 6months to12 years) with mid, distal penile or sub coronal hypospadias having minimal chordae were included in the study
Exclusion criteria
* Patients having proximal hypospadias, moderate to severe chordae, previously operated cases, a preoperative androgens treatment (for example in penoscrotal hypospadias and small sized phallus) were excluded from study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| wound infectiom | 30 days | local wound infection assessed by southampton wound assessment scale where 0 means excellent and 4 means worst |
| frequency of glans dehiscence | 30 days | glans dehiscence observed |
| frequency of meatal stenosis | 30 days | meatal stenosis assessed on examination |
Countries
Pakistan
Outcome results
None listed