Pulmonary Fibrosis, Transbronchial Cryobiopsy
Conditions
Brief summary
The goal of this observational study is to learn about the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy（TBLC） in progressive pulmonary fibrosis.
Detailed description
The goal of this observational study is to learn about the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy（TBLC） in progressive pulmonary fibrosis. The main question it aims to answer are: • The diagnostic rate of MDD1 or MDD2 based on TBLC. • The rate of hemorrhage, pneumothorax, acute ILD exacerbation and mortality. Participants' medical records will be collected by us.
Interventions
None listed
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Patients with PPF, ≥18 years of age, unclassified ILD, HRCT ≤3 months, forced vital capacity (FVC)≥50% predicted value, pulmonary carbon monoxide diffusion (DLCO)≥35% predicted value, echocardiography ≤12 months, estimated pulmonary systolic blood pressure ≤40 mmHg, Body mass index (BMI)≤35 kg/m2.
Exclusion criteria
Patients with platelet counts below 50,000e+9/L or International Normalized ratio of prothrombin time (INR) above 1.5 are not eligible for TBLC
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The diagnostic rate of MDD2 based on TBLC | December，31，2024 | the diagnostic rate of progressive pulmonary fibrosis after Transbronchial Cryobiopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The diagnostic rate of MDD1 | December，31，2024 | the diagnostic rate of progressive pulmonary fibrosis before Transbronchial Cryobiopsy |
Contacts
Primary ContactGang Hou, Professor
Backup ContactMingming Deng, PhD
Outcome results
None listed