Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD

Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in Chronic Obstructive Pulmonary Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06275230

Enrollment

Registered

2024-02-23

Start date

2024-03-20

Completion date

2025-12-31

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD, organoid, human lung stem cells

Brief summary

The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are: * Can human lung stem cell proliferate in vitro. * Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

* 1\. Age under 55, regardless of gender * 2\. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy * 3\. No genetic diseases and other respiratory diseases

Exclusion criteria

* Other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases

Design outcomes

Primary

Measure	Time frame
Number of Patients completed bronchoscope.	1 day

Countries

China

Contacts

Primary ContactMingming Deng, MD

isdeng1017@163.com+8618801336854

Outcome results