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Responses to E-cigarette Message Source and Presentation

Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 1

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06274723
Enrollment
848
Registered
2024-02-23
Start date
2024-11-05
Completion date
2024-12-17
Last updated
2026-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaping

Brief summary

The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape.

Interventions

Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.

Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.

Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.

Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Sponsors

National Cancer Institute (NCI)
CollaboratorNIH
University of Massachusetts, Worcester
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 24 Years
Healthy volunteers
Yes

Inclusion criteria

* US residents ages 18-24 * Fluent in English * Reporting either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping

Exclusion criteria

* Age less than 18 or above 24 * Not fluent in English * Not a member of partnering crowdsourcing behavioral research platform conducting the study

Design outcomes

Primary

MeasureTime frameDescription
Message AcceptanceAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Participants' self-reported message acceptance were measured by using a five-point Likert scale using five items assessing whether participants thought the message was worth remembering, grabbed their attention, powerful, convincing, and meaningful on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more more message acceptance, therefore better outcomes.
Harm PerceptionsAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Harm perceptions was measured by a single item e-cigarette harm perceptions question assessing participants' perceived absolute harm of e-cigarette use on a scale from 1 (Not at all harmful) to 10 (Very harmful). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping harm perceptions, therefore indicating better outcome.

Secondary

MeasureTime frameDescription
Message LikingAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Message liking will be measured by a single-item liking of the message on scale from 1 (Dislike very much) to 5 (Like very much). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater message liking, therefore indicating better outcome.
Source TrustAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Source trust was measured by a single-item trust in health information source questionnaire, such as trust in source about vaping information on a scale from 1(Not at all) to 5 (Very much so). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater source trust, therefore indicating better outcome
Negative CognitionAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Negative cognition was measured by six-item reactance questionnaire, such as perceptions of messages being manipulative, misleading, distorted, overblown, exaggerated, and overstated on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Higher scores indicate greater negative cognition, indicating worse outcome.
Behavioral Intentions to Vape or Try VapingAfter exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.Participants' vaping or vaping trial intentions were measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.
AttitudesAfter exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.
Message AngerAfter exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.Message anger was measured by four item message anger question assessing the extent to which the messages made participants feel irritated, angry, annoyed, and aggravated on a scale from 1 (not at all) to 5 (very much). Items were summed and averaged. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater anger toward messages, indicating worse outcomes.

Countries

United States

Participant flow

Pre-assignment details

n=109 data were removed from analysis; if 1) study duration was less than the average study duration (i.e., 8 minutes; n=44, if the participant age exceeded the eligible age (n=19); and if non-vapers did not meet the susceptibility criteria (n=46).

Participants by arm

ArmCount
Expert, One-Sided
Participants first saw a brief description of a expert source. Then they viewed an e-cigarette message that discussed only the health harms of e-cigarette use. This sequence was repeated 18 times during a single study visit.
191
Expert, Two-Sided
Participants first saw a brief description of an expert source. They then viewed an e-cigarette message that acknowledged both the potential benefits of e-cigarette use and the associated health risks. This sequence was repeated 18 times during a single study visit.
197
Peer, One-Sided
Participants first saw a brief description of a peer source. They then viewed an e-cigarette message that discussed only the health harms of e-cigarette use. This sequence was repeated 18 times during a single study visit.
203
Peer, Two-Sided
Participants first saw a brief description of an peer source. They then viewed an e-cigarette message that acknowledged both the potential benefits of e-cigarette use and the associated health risks. This sequence was repeated 18 times during a single study visit.
194
Total785

Baseline characteristics

CharacteristicExpert, One-SidedExpert, Two-SidedPeer, One-SidedPeer, Two-SidedTotal
Age, Continuous22.04 years
STANDARD_DEVIATION 1.79
21.78 years
STANDARD_DEVIATION 1.77
21.88 years
STANDARD_DEVIATION 1.69
21.85 years
STANDARD_DEVIATION 1.83
21.89 years
STANDARD_DEVIATION 1.77
Ethnicity (NIH/OMB)
Hispanic or Latino
23 Participants24 Participants29 Participants26 Participants102 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
168 Participants173 Participants174 Participants168 Participants683 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
American Indian or Alaska Native
1 Participants0 Participants2 Participants2 Participants5 Participants
Race (NIH/OMB)
Asian
21 Participants20 Participants18 Participants22 Participants81 Participants
Race (NIH/OMB)
Black or African American
43 Participants50 Participants49 Participants53 Participants195 Participants
Race (NIH/OMB)
More than one race
10 Participants16 Participants8 Participants13 Participants47 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
1 Participants0 Participants1 Participants1 Participants3 Participants
Race (NIH/OMB)
Unknown or Not Reported
18 Participants15 Participants27 Participants15 Participants75 Participants
Race (NIH/OMB)
White
97 Participants96 Participants98 Participants88 Participants379 Participants
Region of Enrollment
United States
191 participants197 participants203 participants194 participants785 participants
Sex/Gender, Customized
Female
89 Participants101 Participants92 Participants88 Participants370 Participants
Sex/Gender, Customized
Male
93 Participants83 Participants101 Participants92 Participants369 Participants
Sex/Gender, Customized
Others
9 Participants13 Participants10 Participants14 Participants46 Participants
Vaping status
Current vapers
103 Participants112 Participants115 Participants100 Participants430 Participants
Vaping status
Others
9 Participants11 Participants14 Participants12 Participants46 Participants
Vaping status
Susceptible non-vapers
79 Participants74 Participants74 Participants82 Participants309 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
EG003
affected / at risk
deaths
Total, all-cause mortality
0 / 1910 / 1970 / 2030 / 194
other
Total, other adverse events
0 / 1910 / 1970 / 2030 / 194
serious
Total, serious adverse events
0 / 1910 / 1970 / 2030 / 194

Outcome results

Primary

Harm Perceptions

Harm perceptions was measured by a single item e-cigarette harm perceptions question assessing participants' perceived absolute harm of e-cigarette use on a scale from 1 (Not at all harmful) to 10 (Very harmful). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping harm perceptions, therefore indicating better outcome.

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedHarm PerceptionsCurrent vapers7.39 units on a scaleStandard Deviation 0.2
Expert, One-SidedHarm PerceptionsSusceptible non-vapers8.05 units on a scaleStandard Deviation 0.19
Expert, Two-SidedHarm PerceptionsSusceptible non-vapers8.04 units on a scaleStandard Deviation 0.2
Expert, Two-SidedHarm PerceptionsCurrent vapers7.45 units on a scaleStandard Deviation 0.19
Peer, One-SidedHarm PerceptionsCurrent vapers7.27 units on a scaleStandard Deviation 0.19
Peer, One-SidedHarm PerceptionsSusceptible non-vapers8.04 units on a scaleStandard Deviation 0.2
Peer, Two-SidedHarm PerceptionsCurrent vapers7.44 units on a scaleStandard Deviation 0.2
Peer, Two-SidedHarm PerceptionsSusceptible non-vapers7.82 units on a scaleStandard Deviation 0.19
Primary

Message Acceptance

Participants' self-reported message acceptance were measured by using a five-point Likert scale using five items assessing whether participants thought the message was worth remembering, grabbed their attention, powerful, convincing, and meaningful on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more more message acceptance, therefore better outcomes.

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedMessage AcceptanceCurrent vapers3.01 units on a scaleStandard Deviation 0.01
Expert, One-SidedMessage AcceptanceSusceptible non-vapers2.94 units on a scaleStandard Deviation 0.09
Expert, Two-SidedMessage AcceptanceSusceptible non-vapers2.77 units on a scaleStandard Deviation 0.03
Expert, Two-SidedMessage AcceptanceCurrent vapers3.00 units on a scaleStandard Deviation 0.01
Peer, One-SidedMessage AcceptanceCurrent vapers2.88 units on a scaleStandard Deviation 0.01
Peer, One-SidedMessage AcceptanceSusceptible non-vapers2.77 units on a scaleStandard Deviation 0.09
Peer, Two-SidedMessage AcceptanceCurrent vapers2.76 units on a scaleStandard Deviation 0.01
Peer, Two-SidedMessage AcceptanceSusceptible non-vapers2.72 units on a scaleStandard Deviation 0.09
Secondary

Attitudes

Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.

Time frame: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedAttitudesCurrent vapers2.57 units on a scaleStandard Deviation 0.76
Expert, One-SidedAttitudesSusceptible non-vapers1.51 units on a scaleStandard Deviation 0.81
Expert, Two-SidedAttitudesSusceptible non-vapers1.53 units on a scaleStandard Deviation 0.94
Expert, Two-SidedAttitudesCurrent vapers2.66 units on a scaleStandard Deviation 0.81
Peer, One-SidedAttitudesCurrent vapers2.73 units on a scaleStandard Deviation 0.83
Peer, One-SidedAttitudesSusceptible non-vapers1.41 units on a scaleStandard Deviation 0.72
Peer, Two-SidedAttitudesCurrent vapers2.61 units on a scaleStandard Deviation 0.8
Peer, Two-SidedAttitudesSusceptible non-vapers1.33 units on a scaleStandard Deviation 0.59
Secondary

Behavioral Intentions to Vape or Try Vaping

Participants' vaping or vaping trial intentions were measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.

Time frame: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedBehavioral Intentions to Vape or Try VapingCurrent vapers3.08 units on a scaleStandard Deviation 1.1
Expert, One-SidedBehavioral Intentions to Vape or Try VapingSusceptible non-vapers1.51 units on a scaleStandard Deviation 0.81
Expert, Two-SidedBehavioral Intentions to Vape or Try VapingSusceptible non-vapers1.53 units on a scaleStandard Deviation 0.94
Expert, Two-SidedBehavioral Intentions to Vape or Try VapingCurrent vapers2.88 units on a scaleStandard Deviation 1.14
Peer, One-SidedBehavioral Intentions to Vape or Try VapingCurrent vapers3.05 units on a scaleStandard Deviation 1.23
Peer, One-SidedBehavioral Intentions to Vape or Try VapingSusceptible non-vapers1.41 units on a scaleStandard Deviation 0.72
Peer, Two-SidedBehavioral Intentions to Vape or Try VapingCurrent vapers3.07 units on a scaleStandard Deviation 1.15
Peer, Two-SidedBehavioral Intentions to Vape or Try VapingSusceptible non-vapers1.33 units on a scaleStandard Deviation 0.59
Secondary

Message Anger

Message anger was measured by four item message anger question assessing the extent to which the messages made participants feel irritated, angry, annoyed, and aggravated on a scale from 1 (not at all) to 5 (very much). Items were summed and averaged. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater anger toward messages, indicating worse outcomes.

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedMessage AngerCurrent vapers4.07 units on a scaleStandard Deviation 0.08
Expert, One-SidedMessage AngerSusceptible non-vapers4.42 units on a scaleStandard Deviation 0.07
Expert, Two-SidedMessage AngerSusceptible non-vapers4.57 units on a scaleStandard Deviation 0.07
Expert, Two-SidedMessage AngerCurrent vapers4.12 units on a scaleStandard Deviation 0.08
Peer, One-SidedMessage AngerCurrent vapers4.19 units on a scaleStandard Deviation 0.08
Peer, One-SidedMessage AngerSusceptible non-vapers4.54 units on a scaleStandard Deviation 0.07
Peer, Two-SidedMessage AngerCurrent vapers4.05 units on a scaleStandard Deviation 0.08
Peer, Two-SidedMessage AngerSusceptible non-vapers4.56 units on a scaleStandard Deviation 0.07
Secondary

Message Liking

Message liking will be measured by a single-item liking of the message on scale from 1 (Dislike very much) to 5 (Like very much). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater message liking, therefore indicating better outcome.

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedMessage LikingSusceptible non-vapers3.03 units on a scaleStandard Error 0.07
Expert, One-SidedMessage LikingCurrent vapers3.08 units on a scaleStandard Error 0.09
Expert, Two-SidedMessage LikingSusceptible non-vapers2.97 units on a scaleStandard Error 0.07
Expert, Two-SidedMessage LikingCurrent vapers3.05 units on a scaleStandard Error 0.08
Peer, One-SidedMessage LikingCurrent vapers2.95 units on a scaleStandard Error 0.08
Peer, One-SidedMessage LikingSusceptible non-vapers3.02 units on a scaleStandard Error 0.07
Peer, Two-SidedMessage LikingCurrent vapers2.97 units on a scaleStandard Error 0.09
Peer, Two-SidedMessage LikingSusceptible non-vapers3.00 units on a scaleStandard Error 0.07
Secondary

Negative Cognition

Negative cognition was measured by six-item reactance questionnaire, such as perceptions of messages being manipulative, misleading, distorted, overblown, exaggerated, and overstated on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Higher scores indicate greater negative cognition, indicating worse outcome.

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedNegative CognitionCurrent vapers3.79 units on a scaleStandard Deviation 0.08
Expert, One-SidedNegative CognitionSusceptible non-vapers4.00 units on a scaleStandard Deviation 0.08
Expert, Two-SidedNegative CognitionSusceptible non-vapers4.17 units on a scaleStandard Deviation 0.09
Expert, Two-SidedNegative CognitionCurrent vapers3.81 units on a scaleStandard Deviation 0.08
Peer, One-SidedNegative CognitionCurrent vapers3.87 units on a scaleStandard Deviation 0.08
Peer, One-SidedNegative CognitionSusceptible non-vapers4.12 units on a scaleStandard Deviation 0.09
Peer, Two-SidedNegative CognitionCurrent vapers3.78 units on a scaleStandard Deviation 0.08
Peer, Two-SidedNegative CognitionSusceptible non-vapers4.12 units on a scaleStandard Deviation 0.08
Secondary

Source Trust

Source trust was measured by a single-item trust in health information source questionnaire, such as trust in source about vaping information on a scale from 1(Not at all) to 5 (Very much so). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater source trust, therefore indicating better outcome

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-SidedSource TrustCurrent vapers3.13 units on a scaleStandard Deviation 0.09
Expert, One-SidedSource TrustSusceptible non-vapers3.27 units on a scaleStandard Deviation 0.08
Expert, Two-SidedSource TrustSusceptible non-vapers3.32 units on a scaleStandard Deviation 0.08
Expert, Two-SidedSource TrustCurrent vapers3.21 units on a scaleStandard Deviation 0.08
Peer, One-SidedSource TrustCurrent vapers2.99 units on a scaleStandard Deviation 0.08
Peer, One-SidedSource TrustSusceptible non-vapers3.01 units on a scaleStandard Deviation 0.08
Peer, Two-SidedSource TrustCurrent vapers3.01 units on a scaleStandard Deviation 0.09
Peer, Two-SidedSource TrustSusceptible non-vapers2.96 units on a scaleStandard Deviation 0.08

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026