Uveitis
Conditions
Brief summary
Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases
Interventions
None listed
Sponsors
Meyer Children's Hospital IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of non-infectious chronic uveitis before the age of 16; * signed informed consent form.
Exclusion criteria
* Patients with a diagnosis of infectious uveitis * history of malignant pathology, * history of demyelinating pathology, * history of cerebral vasculitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Describe a population of paediatric patients with chronic non-infectious uveitis | thorugh the study and after 1 year | * Frequency of each aetiology of uveitis * Frequency of signs and symptoms at onset of uveitis * Frequency of laboratory findings * Frequency of each anatomical subtype of uveitis |
| Identify any differences between the different forms of uveitis in terms of characteristics and outcomes | thorugh the study and after 1 year | * Frequency of complications and impaired visual acuity * Description of laboratory characteristics |
| Identify risk factors for a more severe course | thorugh the study and after 1 year | Percentages of children with impaired visual acuity * Percentages of children with ocular complications |
| Frequency achievement of response for each drug according to the definition of response | thorugh the study and after 1 year | Frequency achievement of response for each drug according to the definition of response of the MIWGUC group |
| Time to archieve the response after drug initiation | thorugh the study and after 1 year | Time to archieve the response after drug initiation |
| Achievement of inactive disease on therapy according to the definition of MIWGUC | thorugh the study and after 1 year | Achievement of inactive disease on therapy according to the definition of MIWGUC |
| Time to achieve inactive disease on therapy according to the definition of MIWGUC | thorugh the study and after 1 year | Time to achieve inactive disease on therapy according to the definition of MIWGUC |
| Presence and percentages of flares on therapy after achievement of remission on therapy | thorugh the study and after 1 year | Presence and percentages of flares on therapy after achievement of remission on therapy |
| Time to the first flare on therapy | thorugh the study and after 1 year | Time to the first flare on therapy |
| Time to flare after drug withdrawal | 6, 12 and 18 months, 2 years then every year | Time to flare after drug withdrawal * Proportion of Flare after drug withdrawal in general at the last available follow-up * Proportion of children who flared after drug withdrawal at 6, 12 and 18 months, 2 years then every year |
Countries
Belgium, Greece, Italy, Turkey (Türkiye), United States
Contacts
CONTACTGabriele Simonini
Outcome results
None listed