Preliminary Exploration of Thromboelastography in the Monitoring of Anticoagulation in Maintenance Hemodialysis Patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06272708

Enrollment

200

Registered

2024-02-22

Start date

2024-01-29

Completion date

2024-05-31

Last updated

2024-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anticoagulation, Hemodialysis, Thromboelastography

Brief summary

Objectives: To investigate the role of thromboelastography parameters (R, K, Angle, MA) in monitoring anticoagulation in maintenance hemodialysis (MHD) patients. Subjects: Two hundred stable MHD patients. Methods: An observational study. Primary outcome: Relationship between thromboelastography parameter R Value and coagulation of hemodialysis circuit and dialyzer. Secondary outcome: Relationship between thromboelastography parameters (K Value, Angle and MA) and coagulation of hemodialysis circuit and dialyzer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. male or female patients aged over 18 years 2. stable patients undergoing maintenance hemodialysis treatment for at least 3 months 3. signed informed consent form

Exclusion criteria

1. concomitant with severe diseases such as active malignancy, severe liver diseases, systemic infection, etc. 2. planned or ongoing pregnancy or lactation 3. unsuitable for inclusion in this study after assessment

Design outcomes

Primary

Measure	Time frame	Description
thromboelastography parameter R value	2 hours after hemodialysis began	Relationship between thromboelastography parameter R value and coagulation of hemodialysis circuit and dialyzer

Secondary

Measure	Time frame	Description
thromboelastography parameter K value	2 hours after hemodialysis began	Relationship between thromboelastography parameter K value and coagulation of hemodialysis circuit and dialyzer
thromboelastography parameter Angle	2 hours after hemodialysis began	Relationship between thromboelastography parameter Angle and coagulation of hemodialysis circuit and dialyzer
thromboelastography parameter MA	2 hours after hemodialysis began	Relationship between thromboelastography parameter MA value and coagulation of hemodialysis circuit and dialyzer

Countries

China

Contacts

Primary ContactYiwei Shen, MD

shenyiwei08@126.com0086-18121099413

Outcome results