Endotypic Stability in CRS

Comparison of Endotypic Stability in Various Populations With Chronic Sinusitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06272123

Enrollment

200

Registered

2024-02-22

Start date

2024-01-01

Completion date

2026-01-31

Last updated

2024-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Sinusitis

Brief summary

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Interventions

OTHERno intervention

no intervention

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Patients with Chronic sinusitis (with or without polyps) * Undergoing endoscopic sinus surgery during the study period * More than 18 years * No chronic illness/ malignancy

Design outcomes

Primary

Measure	Time frame	Description
Endotypic markers	1 year	The primary outcome measure assessed through this study is the presence of endotypic markers including: IL-5, IFN-gamma, IL-17a, TNF-alpha, and IL-22 in tissue biopsy samples across multiple racial/ethnic groups.

Secondary

Measure	Time frame	Description
SF-36	1 year	Differences in SF-36 scores between ethnic groups.
SNOT-22	1 year	Differences in SNOT-22 scores between ethnic groups.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026