Postdural Puncture Headache
Conditions
Brief summary
Lumbar puncture (LP), often known as a spinal tap, is a standard medical technique pioneered in the late 1900s by Heinrich Quincke. It involves the retrieval and analysis of cerebrospinal fluid (CSF) from the spinal cord, serving as the benchmark for diagnosing conditions like subarachnoid hemorrhage, meningitis, and specific neurological conditions. Pregabalin, an anticonvulsant medicine that blocks calcium entry, is used to treat a variety of diseases. It has been used to relieve pain in a variety of patient groups, including those with chronic pain, epilepsy, and anxiety disorders
Interventions
DRUGPregabalin 75mg
Group A (pregabalin group) received oral pregabalin treatment administered at 150 mg daily, with 75 mg given every 12 hours.
BIOLOGICALAn epidural blood patch (EBP)
Group B (EBP group) received active therapy in the form of an EBP
COMBINATION_PRODUCTconservative treatment.
Group C (control group) received conservative treatment providing recommendations to the patients, including 24 hours of bed rest, stool softener, and consuming a minimum of 2.0 liters of fluid daily. Analgesics were permitted for pain relief depending on the patient's disease status.
Sponsors
Benha University
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age from 21 to 65 years old, * both genders, * confirmed diagnosis of postdural puncture headache (PDPH)
Exclusion criteria
* patient refusal * known allergy to the drug used in the study * patients with a history of convulsions * chronic headaches * contraindications to regional anesthesia (such as local infection and coagulation abnormalities). * Clinical indications of elevated intracranial pressure or associated risk factors * Deteriorated patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of complete relief | 48 hours | The incidence of complete relief, as reflected in the success rate of the intervention at 48 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The intensity of the headache | 48 hours | The intensity of the headache was measured using visual analogue score (VAS). The scale uses a scoring system in which values of 0, 1-3, 4-6, and 7-10 correspond, respectively, to the absence of pain, mild, moderate, and severe pain. |
Countries
Egypt
Outcome results
None listed