Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI

Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and Mild Cognitive Impairment

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06269939

Enrollment

Registered

2024-02-21

Start date

2025-12-15

Completion date

2027-03-30

Last updated

2026-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Keywords

memory

Brief summary

The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.

Detailed description

Memory enhancing techniques have been incorporated into an 8-session treatment protocol, Strategy Based Training to Enhance Memory (STEM), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants over age 60 how to restructure a memory demanding situation in order to make optimal use of the techniques.

Interventions

BEHAVIORALSTEM

Memory technique training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Inclusion Criteria: * read and speak English fluently

Exclusion criteria

* prior stroke or neurological injury/disease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke). * history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis). * significant alcohol or drug abuse history (inpatient treatment). * Benzodiazepines and steroid use * Diagnosis of dementia

Design outcomes

Primary

Measure	Time frame	Description
Verbal Leaning task	Three points in time: pre-treatment, immediately following treatment, and 6- months after treatment is completed]	Change in total score from Open-Trial Selective Reminding Test (OT-SRT)
Participation in Everyday life	Three points in time: pre-treatment, immediately following treatment, and 6- months after treatment is completed]	Change in total score from Participation Assessment with Recombined Tools

Secondary

Measure	Time frame	Description
Functional Neuroimaging	Two points in time: pre-treatment, immediately following treatment	Change in total scores from memory task during fMRI scan

Countries

United States

Contacts

CONTACTNancy Moore

nbmoore@kesslerfoundation.org19733248450

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 23, 2026