A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults

A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, Randomized, Double- Blind, Parallel-Group, Placebo-Controlled Study

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06269406

Acronym

ICLID

Enrollment

264

Registered

2024-02-21

Start date

2025-07-28

Completion date

2025-09-28

Last updated

2025-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Pain

Keywords

Postoperative Dental Pain, Curcumin and Licorice Root, Ibuprofen, Anti-inflammatory Properties, molars

Brief summary

Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.

Interventions

DIETARY_SUPPLEMENTibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg

The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

DIETARY_SUPPLEMENTibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg

The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure

OTHERThe combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure

The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Removal of 2 to 4 impacted third molars

Exclusion criteria

* Pregnancy or breastfeeding * Ibuprofen contraindications. * Allergy to any of the intervention components.

Design outcomes

Primary

Measure	Time frame
Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points)	8 hours

Secondary

Measure	Time frame
Total pain relief (TOTPAR) %	8 hours
Time to pain half pain gone (in minutes)	8 hours
Duration of pain half gone (in minutes)	8 hours
Any adverse events (facial swelling, nausea, vomiting, headache) (%)	8 hours

Countries

Russia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026