Skip to content

Responses to Message Source and Presentation Using Psychophysiology

Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 2

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06269003
Enrollment
112
Registered
2024-02-21
Start date
2024-02-18
Completion date
2024-06-10
Last updated
2025-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaping

Brief summary

The goal of this clinical trial is to use psychophysiological methods to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape.

Interventions

Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.

Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.

Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.

Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Sponsors

National Cancer Institute (NCI)
CollaboratorNIH
University of Massachusetts, Worcester
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 24 Years
Healthy volunteers
Yes

Inclusion criteria

* Ages 18-24 * Fluent in English * Either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping * Self-reported abstinence of combusted tobacco or marijuana at time of visit

Exclusion criteria

* Ages below 18 or above 24 * Not fluent in English * Not confirmed self-reported abstinence of combusted tobacco or marijuana at time of visit

Design outcomes

Primary

MeasureTime frameDescription
Visual AttentionThe entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.Visual attention was assessed by measuring dwell time, which is the length of time participants spent on looking at the specific areas of interest (AOIs) collected in miliseconds. Dwell time values were collected for 18 messages, and aggregated to provide the average dwell time scores for each arm. This was done for each vaping status (current vapers and susceptible non-vapers). Higher dwell time scores indicate higher visual attention, indicating better message outcomes.
Allocation of Cognitive ResourcesBaseline and immediately after viewing all the messages (approximately 45 minutes).Heart rate values were collected in beats per minute (BPM) on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in the BPM values during the message exposure period by comparing the BPM values collected during each message second to the BPM values collected during the immediately preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean BPM value per condition, and this was done for each vaping status (current vapers and susceptible non-vapers). Lower BPM values reflect greater cognitive response, therefore indicate better message outcomes.
ArousalBaseline and immediately after viewing all the messages (approximately 45 minutes).Galvanic Skin Response (GSR) values were recorded in microsiemens on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in GSR values by comparing each message response to its preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean GSR score per condition, and this was done for each vaping status group (current vapers and susceptible non-vapers). Higher GSR values reflect greater physiological arousal, and indicate better message outcomes.

Secondary

MeasureTime frameDescription
AttitudesAfter exposure to all messages, approximately up to 45 minutes.Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.
Behavioral IntentionsAfter exposure to all messages, approximately up to 45 minutes.Participants' vaping intentions was measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.

Countries

United States

Participant flow

Recruitment details

Participants were recruited based on their age (18-24 years old), vaping status (past-30-day vaping and/susceptible to vaping), location (living in the US) between January 2024 to June 2024. The first participant was enrolled in February 18, 2024, and the last participant was enrolled in June 10, 2024.

Participants by arm

ArmCount
Expert, One-sided
Participants first saw a brief description of a expert source. Then they viewed an e-cigarette message that discussed only the health harms of e-cigarette use. This sequence was repeated 18 times during a single study visit.
28
Peer, One-sided
Participants first saw a brief description of a peer source. They then viewed an e-cigarette message that discussed only the health harms of e-cigarette use. This sequence was repeated 18 times during a single study visit.
27
Expert, Two-sided
Participants first saw a brief description of an expert source. They then viewed an e-cigarette message that acknowledged both the potential benefits of e-cigarette use and the associated health risks. This sequence was repeated 18 times during a single study visit.
28
Peer, Two-sided
Participants first saw a brief description of an peer source. They then viewed an e-cigarette message that acknowledged both the potential benefits of e-cigarette use and the associated health risks. This sequence was repeated 18 times during a single study visit.
28
Total111

Withdrawals & dropouts

PeriodReasonFG000FG001FG002FG003
Overall StudyOne participant was excluded for being outside the eligible age range.0010

Baseline characteristics

CharacteristicExpert, One-sidedPeer, One-sidedExpert, Two-sidedPeer, Two-sidedTotal
Age, Continuous22.25 years
STANDARD_DEVIATION 1.4
21.59 years
STANDARD_DEVIATION 2.12
21.57 years
STANDARD_DEVIATION 1.75
21.82 years
STANDARD_DEVIATION 1.85
21.81 years
STANDARD_DEVIATION 1.79
Ethnicity (NIH/OMB)
Hispanic or Latino
3 Participants5 Participants7 Participants3 Participants18 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
25 Participants22 Participants21 Participants25 Participants93 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Asian
3 Participants7 Participants4 Participants6 Participants20 Participants
Race (NIH/OMB)
Black or African American
1 Participants0 Participants1 Participants3 Participants5 Participants
Race (NIH/OMB)
More than one race
2 Participants2 Participants2 Participants1 Participants7 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Unknown or Not Reported
3 Participants1 Participants4 Participants4 Participants12 Participants
Race (NIH/OMB)
White
19 Participants17 Participants17 Participants14 Participants67 Participants
Region of Enrollment
United States
28 Participants27 Participants28 Participants28 Participants111 Participants
Sex/Gender, Customized
Female
14 Participants21 Participants17 Participants18 Participants70 Participants
Sex/Gender, Customized
Male
11 Participants4 Participants9 Participants6 Participants30 Participants
Sex/Gender, Customized
Others
3 Participants2 Participants2 Participants4 Participants11 Participants
Vaping Status
Current vaping
15 Participants14 Participants16 Participants16 Participants61 Participants
Vaping Status
Susceptible to vaping
13 Participants13 Participants12 Participants12 Participants50 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
EG003
affected / at risk
deaths
Total, all-cause mortality
0 / 280 / 280 / 270 / 28
other
Total, other adverse events
0 / 280 / 280 / 270 / 28
serious
Total, serious adverse events
0 / 280 / 280 / 270 / 28

Outcome results

Primary

Allocation of Cognitive Resources

Heart rate values were collected in beats per minute (BPM) on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in the BPM values during the message exposure period by comparing the BPM values collected during each message second to the BPM values collected during the immediately preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean BPM value per condition, and this was done for each vaping status (current vapers and susceptible non-vapers). Lower BPM values reflect greater cognitive response, therefore indicate better message outcomes.

Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).

Population: n=41 were removed from analysis due to poor quality. The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-sidedAllocation of Cognitive ResourcesCurrent vapers-4.885 Beats per minuteStandard Error 1.108
Expert, One-sidedAllocation of Cognitive ResourcesSusceptible non-vapers-3.723 Beats per minuteStandard Error 0.834
Expert, Two-sidedAllocation of Cognitive ResourcesSusceptible non-vapers-3.444 Beats per minuteStandard Error 0.834
Expert, Two-sidedAllocation of Cognitive ResourcesCurrent vapers-4.098 Beats per minuteStandard Error 1.324
Peer, One-sidedAllocation of Cognitive ResourcesCurrent vapers-2.079 Beats per minuteStandard Error 1.239
Peer, One-sidedAllocation of Cognitive ResourcesSusceptible non-vapers-3.232 Beats per minuteStandard Error 0.945
Peer, Two-sidedAllocation of Cognitive ResourcesCurrent vapers-1.652 Beats per minuteStandard Error 1.168
Peer, Two-sidedAllocation of Cognitive ResourcesSusceptible non-vapers-4.696 Beats per minuteStandard Error 1.119
Primary

Arousal

Galvanic Skin Response (GSR) values were recorded in microsiemens on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in GSR values by comparing each message response to its preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean GSR score per condition, and this was done for each vaping status group (current vapers and susceptible non-vapers). Higher GSR values reflect greater physiological arousal, and indicate better message outcomes.

Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).

Population: n=29 were removed from analysis due to poor quality. The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-sidedArousalCurrent vapers17.225 microsiemensStandard Error 272.99
Expert, One-sidedArousalSusceptible non-vapers215.883 microsiemensStandard Error 372.223
Expert, Two-sidedArousalSusceptible non-vapers-9.867 microsiemensStandard Error 372.223
Expert, Two-sidedArousalCurrent vapers597.772 microsiemensStandard Error 272.99
Peer, One-sidedArousalCurrent vapers-49.682 microsiemensStandard Error 285.129
Peer, One-sidedArousalSusceptible non-vapers526.856 microsiemensStandard Error 394.802
Peer, Two-sidedArousalCurrent vapers267.135 microsiemensStandard Error 272.99
Peer, Two-sidedArousalSusceptible non-vapers-157.043 microsiemensStandard Error 372.223
Primary

Visual Attention

Visual attention was assessed by measuring dwell time, which is the length of time participants spent on looking at the specific areas of interest (AOIs) collected in miliseconds. Dwell time values were collected for 18 messages, and aggregated to provide the average dwell time scores for each arm. This was done for each vaping status (current vapers and susceptible non-vapers). Higher dwell time scores indicate higher visual attention, indicating better message outcomes.

Time frame: The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-sidedVisual AttentionCurrent vapers6217.016667 millisecondsStandard Deviation 1278.03706
Expert, One-sidedVisual AttentionSusceptible non-vapers6750.67 millisecondsStandard Deviation 798.60759
Expert, Two-sidedVisual AttentionSusceptible non-vapers6423.3025 millisecondsStandard Deviation 1069.16916
Expert, Two-sidedVisual AttentionCurrent vapers6333.70375 millisecondsStandard Deviation 909.82927
Peer, One-sidedVisual AttentionCurrent vapers6567.725714 millisecondsStandard Deviation 934.62436
Peer, One-sidedVisual AttentionSusceptible non-vapers6701.923077 millisecondsStandard Deviation 604.30866
Peer, Two-sidedVisual AttentionCurrent vapers6667.185625 millisecondsStandard Deviation 633.14744
Peer, Two-sidedVisual AttentionSusceptible non-vapers6231.6275 millisecondsStandard Deviation 933.71167
Secondary

Attitudes

Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.

Time frame: After exposure to all messages, approximately up to 45 minutes.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-sidedAttitudesCurrent vapers1.9619 score on a scaleStandard Deviation 0.45326
Expert, One-sidedAttitudesSusceptible non-vapers1.6593 score on a scaleStandard Deviation 0.40632
Expert, Two-sidedAttitudesSusceptible non-vapers1.5833 score on a scaleStandard Deviation 0.48141
Expert, Two-sidedAttitudesCurrent vapers2.1771 score on a scaleStandard Deviation 0.54931
Peer, One-sidedAttitudesCurrent vapers2.1480 score on a scaleStandard Deviation 0.62299
Peer, One-sidedAttitudesSusceptible non-vapers1.6044 score on a scaleStandard Deviation 0.51228
Peer, Two-sidedAttitudesCurrent vapers1.8824 score on a scaleStandard Deviation 0.39817
Peer, Two-sidedAttitudesSusceptible non-vapers1.8571 score on a scaleStandard Deviation 0.40913
Secondary

Behavioral Intentions

Participants' vaping intentions was measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.

Time frame: After exposure to all messages, approximately up to 45 minutes.

Population: The data were stratified based on participants' vaping status (Current vapers and Susceptible non-vapers). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

ArmMeasureGroupValue (MEAN)Dispersion
Expert, One-sidedBehavioral IntentionsCurrent vapers2.7556 score on a scaleStandard Deviation 0.98776
Expert, One-sidedBehavioral IntentionsSusceptible non-vapers1.3333 score on a scaleStandard Deviation 0.49065
Expert, Two-sidedBehavioral IntentionsSusceptible non-vapers1.0278 score on a scaleStandard Deviation 0.09623
Expert, Two-sidedBehavioral IntentionsCurrent vapers3.0313 score on a scaleStandard Deviation 0.87817
Peer, One-sidedBehavioral IntentionsCurrent vapers3.0238 score on a scaleStandard Deviation 0.90075
Peer, One-sidedBehavioral IntentionsSusceptible non-vapers1.2564 score on a scaleStandard Deviation 0.47442
Peer, Two-sidedBehavioral IntentionsCurrent vapers2.5833 score on a scaleStandard Deviation 0.96992
Peer, Two-sidedBehavioral IntentionsSusceptible non-vapers1.3056 score on a scaleStandard Deviation 0.30011

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026