Menstrual Cycle Phase, Muscle Protein Synthesis
Conditions
Brief summary
The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been conducted exclusively in men or in studies where both men and women are assessed. The increase in muscle mass is thought to be impacted by sex hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis following exercise is not known.
Interventions
OTHERPhase of the menstrual cycle
Follicular or luteal phase
Sponsors
Pvolve
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Randomised cross-over design.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Female, aged 18-40 years * BMI between 18 and 30 kg/m2 * Recreationally active * Regular menstrual cycle
Exclusion criteria
* Smoking or use of tobacco containing products * Irregular menstrual cycle * Currently on any form of hormonal contraception * Post-menopausal * Pregnant or breastfeeding * Diagnosed metabolic/pulmonary/musculoskeletal illness * Diagnosed cardiovascular disease or hypertension * Use of medications that may impact protein metabolism or are anti-inflammatory * Gastrointestinal disorders * Allergy to pomegranate or amino acids * Injuries that would impact ability to complete study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein synthesis | 7 hours | The rate of synthesis of new muscle protein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma amino acid kinetics | 7 hours | The appearance of amino acids in the circulation. |
| Serum insulin concentrations | 7 hours | Basal and postprandial concentrations of serum insulin |
| Sex hormone concentrations | 5 minutes | Serum oestrogen and progesterone |
| Energy expenditure | 20 minutes | Basal metabolic rate |
Countries
United Kingdom
Outcome results
None listed