Chronic Urticaria
Conditions
Keywords
Chronic urticaria, antiplatelet, D-dimer
Brief summary
This study compares the combination of antiplatelets and antihistamine versus antihistamine alone for the treatment of chronic spontaneous urticaria
Detailed description
This study is a randomized control trial comparing the effectiveness of the combination of antiplatelets and antihistamine and antihistamine alone for the treatment of chronic spontaneous urticaria
Interventions
DRUGDesloratadine plus cilostazol and dipyridamole
Desloratadine 20 mg/day plus cilostazol 150 mg/day and dipyridamole 50 mg/day
DRUGDesloratadine
Desloratadine 20 mg/day
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
Identical capsules
Intervention model description
Patients diagnosed with chronic urticaria will be assigned to 2 treatment arms. 1. high dose antihistamine with antiplatelets; and 2. high dose antihistamine alone.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Chronic spontaneous urticaria D-dimer levels over 500 ng/ml Not respond to a conventional dose of antihistamine
Exclusion criteria
Are taking aspirin Have bleeding tendency Have concurrent severe medical illnesses \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weekly urticaria activity score | 4 weeks | Urticaria activity score over 7 days (UAS7): scores 0-42 from mild to severe |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| D-dimer levels | 4 weeks | D-dimer levels |
Countries
Thailand
Outcome results
None listed