Age-related Cognitive Decline, Aging, Aging Disorder, Frailty, LONGEVITY 1
Conditions
Brief summary
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia. The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity. The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.
Detailed description
The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva. Follow-up checks will be carried out once a year by phone or during additional visits. The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.
Interventions
None listed
Sponsors
Pirogov Russian National Research Medical University
Center for Strategic Planning, of the Federal Medical and Biological Agency
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
90 Years to No maximum
Inclusion criteria
* Informed consent * 90 years of age or above
Exclusion criteria
* Refusal to participate or to provide informed consent; * Any other criteria deemed reasons for exclusion by the Principal Investigator.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality among long-living adults | at least 1 year after inclusion in the study | Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed. |
| Morbidity among long-living adults | at least 1 year after inclusion in the study | Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Genetic determinants | at least 2 years after inclusion in the study | Identification of the genetic determinants of successful and unsuccessful aging, geriatric syndromes |
| Aging phenotypes | at least 2 years after inclusion in the study | Identification of successful and unsuccessful aging phenotypes |
| Metagenomic determinants | at least 2 years after inclusion in the study | Identification of the metagenomic determinants (16S-rSeq) of successful and unsuccessful aging, geriatric syndromes |
| Epigenetic determinants | at least 2 years after inclusion in the study | Identification of the epigenetic determinants (methylation sites) of successful and unsuccessful aging, geriatric syndromes |
| Social, economic, and medical- history-related determinants | at least 2 years after inclusion in the study | Identification of social, economic, and medical- history-related determinants of successful and unsuccessful aging, geriatric syndromes |
Countries
Russia
Contacts
Primary ContactDaria A. Kashtanova, M.D., Ph.D
Backup ContactVeronika V. Erema, M.D., Ph.D
Outcome results
None listed