Acute Bronchiolitis Due to Respiratory Syncytial Virus
Conditions
Keywords
Wood-Downes Clinical scoring System
Brief summary
The goal of this clinical trial is to compare the efficacy of hypertonic saline nebulization with adrenaline nebulization in the treatment of acute bronchiolitis in children. Main aim is to evaluate the following in both group of patients 1. Improvement in Wood-Downes clinical score (WDF score) in bronchiolitis 2. Length of Hospitalization
Detailed description
This is a double-blind clinical trial that will include all admitted patients with acute bronchiolitis, meeting inclusion criteria, admitted in Pediatrics department Combined Military Hospital Nowshera. Patients will be divided into two groups randomly. Group I patients will be nebulized with drug adrenaline every 6 hours and group II patients will be nebulized with hypertonic saline every 6 hours. After 24 hours and 48 hours of nebulization, researchers will record WDF score by measuring respiratory rate, heart rate, chest retractions, chest auscultation findings and SPO₂ levels. All data will be recorded on a research Performa including length of hospital stay. Data will be entered on SPSS to calculate results. Independent sample t-test was used to measure the effect of two drugs on the length of hospital stay and improvement of respiratory score with a 95% confidence interval. P value less than 0.05 will be considered as significant.
Interventions
Dilute 0.3 ml hypertonic saline with 3 ml normal saline for nebulization
DRUGAdrenaline
dilute 0.3 ml adrenaline with 3 ml normal saline for nebulization
Sponsors
Combined Military Hospital, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
Investigator will make all the protocol and research Performa. Drugs will already be prepared for nebulization and labelled by investigator. Researcher /care provider will nebulize the patients of both groups randomly and record the results accordingly.
Intervention model description
Patients with acute bronchiolitis after informed written consent will be divided into two groups randomly. Group I will be nebulized with adrenaline every 6 hours and group II will nebulized with hypertonic saline every 6 hours. After 24 hours and 48 hours of nebulization, WDF score will be recorded by measuring respiratory rate, heart rate, chest retractions, chest auscultation findings and SPO₂ levels. Researcher will record all data on a specified Performa.
Eligibility
Sex/Gender
ALL
Age
1 Months to 2 Years
Healthy volunteers
No
Inclusion criteria
* All children admitted in PICU with acute bronchiolitis
Exclusion criteria
* children with co-exiting illnesses like 1. Congenital Heart Disease 2. Immunodeficiency 3. other Infectious disease like Meningitis, encephalitis, Pneumonia, TORCH 4. Kidneys or liver problem 5. Seizures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wood-Downes-Ferres clinical score calculation | at 24 and 48 hours of treatment | A score of 0-3 mild, 4-6 moderately ill, \>6 severely ill |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| total length of hospitalization | less than 7 days, 7-10 days, 10-14 days | less than 1 week, more than 1 week, |
Countries
Pakistan
Contacts
Primary ContactSyed Qamar Zaman
Backup ContactMadeeha Qamar
Outcome results
None listed