Vesicle
Conditions
Keywords
MICROVESCICLES; CIRRHOSIS; HCC; NANOSTRUCTURES.
Brief summary
Extracellular vesicles, due to their ease of extraction and ability to represent the cells from which they originate, have high potential in the field of personalized medicine, especially in the identification of new early bio-markers of cancer, including hepatocellular carcinoma. Nevertheless, the development of high-throughput diagnostic methods in this area is still in its infancy, and the design of new integrated technological solutions is of great interest and topicality. The main hypothesis of this study is that the development of a novel technology integrating resonant gold nanostructures in the mid-infrared can significantly contribute to the development of new approaches for the diagnosis of hepatocellular carcinoma.
Interventions
DIAGNOSTIC_TESTsierological test
sierological test: circulant vescicles
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inclusion * 18 years old with a diagnosis of liver cirrhosis of different etiology * 18 years old with a diagnosis of hepatocellular carcinoma Exclusion * Have not signed the informed consent * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| primary endpoint | 12 months | To evaluate the change in extracellular vesicle concentration between the control group and oncology group. The concentration of vesicles per ml of blood will be measured by frequency shift of the plasmonic resonance peak of gold nanostructures following immuno-capture of vesicles. |
Countries
Italy
Contacts
Primary ContactFABRIZIO PIZZOLANTE, MD PhD
Backup ContactGabriele Ciasca, Professor
Outcome results
None listed