Dysplasia, Inflammatory Bowel Diseases
Conditions
Brief summary
Dye- spray chromoendoscopy remains the recommended gold standard approach for IBD dysplasia surveillance colonoscopy however recently published European and American guidelines recommend either dye-spray or virtual chromoendoscopy can be used for surveillance. The newer Imaged Enhanced Endoscopy technologies TXI and LCI have not formally been evaluated in IBD surveillance in a randomised controlled trial setting. These modes can easily be applied during colonoscopy and if demonstrated to be effective may save time and eliminate the need for dye-spray chromoendoscopy in the future.
Interventions
PROCEDUREImage Enhanced Endoscopy Filters
Patients that undergoing surveillance and consent to be involved in the study will be randomised to undergo surveillance with LCI, TXI or dye-spray chromoendoscopy (methylene blue).
Sponsors
Royal Perth Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with inflammatory bowel disease aged 18 to 75 years, that meet Australian recommendations to undergo surveillance colonoscopy will be identified and invited participate in the study.
Exclusion criteria
* Any active disease * Inadequate bowel preparation * Previous surgical resection involving the colon * History of bowel cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dysplasia Detection Rate | 2 years | Overall Dysplasia Detection rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Withdrawal times | 2 years | Withdrawal time for procedure |
| Characterisation of lesions | 2 years | Accurate characterisation compared to histology |
Countries
Australia
Contacts
Primary ContactSherman Picardo, MBBS (hon), MSc
Outcome results
None listed