Postoperative Infectious Complications Calculator for Elderly Patients

Postoperative Infectious Complications Calculator for Elderly Patients--A Derivation and External Validation of Prediction Models Based on Two Centers Large Sample

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06265493

Enrollment

37230

Registered

2024-02-20

Start date

2021-06-01

Completion date

2023-09-30

Last updated

2024-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geriatrics, Postoperative Infection, Prediction

Keywords

postoperative infectious complications, elderly patients, retrospective study, prediction model, calculator

Brief summary

The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients. Our scoring system can aid in the early detection of potential risks for postoperative infections. Higher-score patients were more likely to experience postoperative infections.

Detailed description

Background: Postoperative infectious complications (PICs) are related to increased morbidity, mortality, and costs, especially in elderly patients. However, published prediction models of PICs are rarely based on elderly patients. Objective: The study wanted to identify practical and valuable variables that could be used to predict postoperative infections and establish a convenient scoring system for clinicians to assess the risk of such conditions in elderly patients. Methods： Data from 2 population-based cohorts of elderly patients undergoing non-cardiac and non-neurology surgery were used to derive and validate multivariable logistic regression models. The risk prediction models were derived from 37230 patients hospitalized in the First Medical Center of the Chinese PLA General Hospital (January 2012 - August 2018). The risk prediction models were externally validated with data from a cohort of 10252 patients hospitalized in Henan Provincial People's Hospital (November 2014 to May 2022).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

1. age ≥ 65 years and 2. patients undergoing surgery with anesthesia.

Exclusion criteria

1. patients undergoing neurosurgery or cardiac surgery, 2. preoperative infectious diseases, and 3. patients with ≥50% of data missing.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Infectious Complications Calculator for Elderly Patients	January 2012 - August 2018	A Derivation and External Validation of Prediction Models based on two centers large sample

Countries

China

Outcome results